gene

KDM6A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDM6A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

149Connections

1Hypotheses

1Analyses

50Outgoing

45Incoming

6Experiments

1Debates

Summary

Lysine Specific Demethylase 6A (UTX) - histone demethylase regulating gene expression in neurodevelopment and neurodegeneration

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🧬 Gene Info

Gene Symbol	KDM6A
Aliases	Lysine Specific Demethylase 6A (UTX), Lysine Specific Demethylase 6A (UTX
Protein Type	Epigenetic Regulator
Target Class	Epigenetic Regulator
Function	Small molecule inhibition of histone demethylase activity
Mechanism of Action	Small molecule inhibition of histone demethylase activity
Druggability	Low (0.35)
Clinical Stage	Phase I
Molecular Weight	160 kDa
Amino Acids	401 aa
Exons	29
Pathways	Epigenetic
UniProt ID	A0A087X0R0
GeneCards	KDM6A
Human Protein Atlas	KDM6A
Associated Diseases	cancer, inflammation, neurodegeneration, OXIDATIVE STRESS, SYNAPTIC PLASTICITY
Known Drugs/Compounds	GSK-J4
Interactions	App, ASCL1, ATM, BRCA2, BRG1, C1Q
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	KDM6A-Mediated H3K27me3 Rejuvenation
KG Connections	149 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KDM6A — AlphaFold A0A087X0R0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KDM6A Gene

gene · 1516 words

→

KDM6A Protein (Lysine Specific Demethylase 6A (UTX))

protein · 624 words

→

Pathway Diagram

graph TD
    KDM6A["KDM6A"]
    neurodegeneration{"neurodegeneration"}
    KDM6A -->|"implicated in"| neurodegeneration
    KDM6A -->|"associated with"| neurodegeneration
    SIRT6["SIRT6"]
    KDM6A -->|"co discussed"| SIRT6
    DNMT1["DNMT1"]
    KDM6A -->|"co discussed"| DNMT1
    FOXO3["FOXO3"]
    KDM6A -->|"co discussed"| FOXO3
    h_881362dc["h-881362dc"]
    h_881362dc -->|"therapeutic target"| KDM6A
    h_881362dc -->|"targets"| KDM6A
    HDAC3["HDAC3"]
    HDAC3 -->|"co discussed"| KDM6A
    TET2["TET2"]
    TET2 -->|"co discussed"| KDM6A
    style KDM6A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (104)

Target	Relation	Type	Str
H3K27me3	demethylates	histone_mark	0.80
MMP3	inhibits	gene	0.70
CREB	interacts_with	gene	0.70
Als	regulates	disease	0.65
Spinal Cord Injury	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Lung Cancer	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Aging	treats	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Prostate Cancer	treats	disease	0.65
Als	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
AKT	regulates	gene	0.60
MTOR	activates	gene	0.60
NEUROD1	activates	gene	0.60
FGFR3	therapeutic_target	gene	0.60
FGFR3	activates	gene	0.60
SUCCINATE	produces	phenotype	0.60
KDM1A	targets	gene	0.60
CANCER	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
Mtor	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Histone Modification	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
ROS	inhibits	gene	0.60
RNA	inhibits	gene	0.60
PI3K	activates	gene	0.60
EGFR	regulates	gene	0.60
GBM	activates	gene	0.60
GLUD1	regulates	gene	0.60
DNA	inhibits	gene	0.60
Immune Checkpoint	treats	pathway	0.60
CANCER	inhibits	gene	0.60
GENES	inhibits	gene	0.60
AGING	treats	gene	0.60
Checkpoint Inhibitor	treats	pathway	0.60
Adaptive Immunity	treats	pathway	0.60
Immunotherapy	treats	pathway	0.60
Epigenetic	regulates	pathway	0.60
EZH2	inhibits	gene	0.60
Nk Cell	regulates	cell_type	0.60
spinal cord	expressed_in	brain_region	0.60

Incoming (45)

Source	Relation	Type	Str
h-881362dc	targets	hypothesis	0.90
PDPK1	activates	gene	0.60
TP53	therapeutic_target	gene	0.60
KMT2D	associated_with	gene	0.60
RB1	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
TP53	activates	gene	0.60
OVERVIEW	activates	gene	0.60
RB1	activates	gene	0.60
PIK3CA	activates	gene	0.60
HK2	activates	gene	0.60
EZH2	activates	gene	0.60
GENES	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
ASCL1	activates	gene	0.60
CSF	stabilizes	phenotype	0.60
CANCER	activates	gene	0.60
CD38	regulates	gene	0.60
PTEN	inhibits	gene	0.60
CREB	activates	gene	0.55
DNA	activates	gene	0.55
CBP	activates	gene	0.55
KDM1A	activates	gene	0.55
BRG1	activates	gene	0.55
C1Q	activates	gene	0.55
CANCER	associated_with	disease	0.50
ALZHEIMER'S DISEASE	associated_with	disease	0.50
ALZHEIMER	associated_with	disease	0.50
STROKE	associated_with	disease	0.50
SPINAL CORD INJURY	associated_with	disease	0.45
DNMT1	debate_co_mention	gene	0.45
FOXO3	debate_co_mention	gene	0.45
HDAC3	debate_co_mention	gene	0.45
CLOCK	debate_co_mention	gene	0.45
SPINAL CORD	associated_with	brain_region	0.45
HDAC	debate_co_mention	gene	0.45
FOXO3	co_discussed	gene	0.40
HDAC	co_discussed	gene	0.40
DNMT1	co_associated_with	gene	0.40
TET2	co_discussed	gene	0.40
DNMT1	co_discussed	gene	0.40
SIRT6	co_discussed	gene	0.40
HDAC3	co_discussed	gene	0.40
HDAC3	co_associated_with	gene	0.40
FOXO3	co_associated_with	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
KDM6A-Mediated H3K27me3 Rejuvenation	0.653	neurodegeneration	Epigenetic clocks and biological aging i

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.710

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Proposed experiment from debate on Epigenetic clocks and biological ag	falsification	Neurodegeneration	0.400	0.50	mouse	completed	$450,000
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis	clinical	Alzheimer's Disease	0.400	0.50	human	completed	$6,550,000
DNA Damage Repair Deficiency Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	completed	$7,500,000
Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Mar	validation	Neurodegeneration	0.400	0.50	human	completed	$3,000,000
Epigenetic Dysregulation in Huntington's Disease — Therapeutic Targeti	validation	Neurodegeneration	0.400	0.50	human	completed	$3,000,000
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo	validation	Parkinson's Disease	0.400	0.50	human	completed	$2,730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a sp [PMID:22729224]	["Rivi\u00e8re J", "Mirzaa G", "O'Roak B	Nature Genetics	2012	748
High-Resolution Differentiation of Enteric Bacteria in Premature Infant Fecal Mi [PMID:33593974]	Graf J, Ledala N, Caimano MJ, Jackson E,	mBio	2021	1
Development of a deep learning-based software for calculating cleansing score in [PMID:33627678]	Nam JH, Hwang Y, Oh DJ, Park J, Kim KB,	Sci Rep	2021	1
Bacterial siderophores in community and host interactions. [PMID:31748738]	Kramer J, Özkaya Ö, Kümmerli R	Nat Rev Microbiol	2020	1
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans. [PMID:33398264]	Turner JS, Kim W, Kalaidina E, Goss CW,	Res Sq	2020	1
ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration [PMID:30683808]	Griffin EF, Scopel SE, Stephen CA, Holzh	Dis Model Mech	2019	1
Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygot [PMID:31167141]	Paraiso KD, Blitz IL, Coley M, Cheung J,	Cell Rep	2019	1
Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cance [PMID:25219498]	Yoo HM, Kang SH, Kim JY, Lee JE, Seong M	Mol Cell	2014	1
Foxh1 is a locus-specific PRC2 recruiter governing germ layer silencing. [PMID:41040321]	["Cho J", "Hendrickson C", "Mar N", "Bli	bioRxiv : the preprint server	2025	0
Epigenetic regulation of bladder cancer in the context of aging. [PMID:40918525]	["Liu X", "Ding G", "Liu Y", "Yan X", "Z	Frontiers in pharmacology	2025	0
Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation [PMID:38926506]	Seehawer M, Li Z, Nishida J, Foidart P,	Nature cell biology	2024	0
Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multipl [PMID:38355622]	Liu J, Xing L, Li J, Wen K, Liu N, Liu Y	Nature communications	2024	0
Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of hum [PMID:39232216]	Tamagawa H, Fujii M, Togasaki K, Seino T	Nature cell biology	2024	0
KDM6A epigenetically regulates subtype plasticity in small cell lung cancer. [PMID:37591951]	Duplaquet L, Li Y, Booker MA, Xie Y, Ols	Nature cell biology	2023	0
H3K36 dimethylation shapes the epigenetic interaction landscape by directing rep [PMID:35396277]	["Chen H", "Hu B", "Horth C", "Bareke E"	Genome research	2022	0
An intramembrane chaperone complex facilitates membrane protein biogenesis. [PMID:32814900]	["Chitwood PJ", "Hegde RS"]	Nature	2020	0
In vitro anti-HIV-1 activity of the bioactive compound extracted and purified fr [PMID:31434919]	["Sanniyasi E", "Venkatasubramanian G",	Scientific reports	2019	0
Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation an [PMID:31747604]	Yamagishi M, Hori M, Fujikawa D, Ohsugi	Cell reports	2019	0
Benefit of Adjuvant Chemoradiotherapy in Resected Gallbladder Carcinoma. [PMID:31409811]	["Kim T", "Woo S", "Lee W", "Oh E", "You	Scientific reports	2019	0
Opportunities and obstacles for deep learning in biology and medicine. [PMID:29618526]	["Ching T", "Himmelstein D", "Beaulieu-J	Journal of the Royal Society,	2018	0

Debates (1)

Multi-agent debates referencing this entity

Epigenetic clocks and biological aging in neurodegeneration

closed · Rounds: 4 · Score: 0.93 · 2026-04-06

Related Research

Hypotheses and analyses mentioning KDM6A in their description or question text

No additional research found