| Gene Symbol | KDM6A |
| Aliases | Lysine Specific Demethylase 6A (UTX), Lysine Specific Demethylase 6A (UTX |
| Protein Type | Epigenetic Regulator |
| Target Class | Epigenetic Regulator |
| Function | Small molecule inhibition of histone demethylase activity |
| Mechanism of Action | Small molecule inhibition of histone demethylase activity |
| Druggability | Low (0.35) |
| Clinical Stage | Phase I |
| Molecular Weight | 160 kDa |
| Amino Acids | 401 aa |
| Exons | 29 |
| Pathways | Epigenetic |
| UniProt ID | A0A087X0R0 |
| GeneCards | KDM6A |
| Human Protein Atlas | KDM6A |
| Associated Diseases | cancer, inflammation, neurodegeneration, OXIDATIVE STRESS, SYNAPTIC PLASTICITY |
| Known Drugs/Compounds | GSK-J4 |
| Interactions | App, ASCL1, ATM, BRCA2, BRG1, C1Q |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | X-Linked KDM6A Escapes X-Inactivation to Drive Fem KDM6A-Mediated H3K27me3 Rejuvenation |
| KG Connections | 149 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!