protein

KDM1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDM1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

19Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for KDM1A Protein (Lysine Specific Demethylase 1A (LSD1))

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🔬 Protein Info

Gene Symbol	KDM1A
Full Name	Lysine Specific Demethylase 1A
Aliases	Lysine Specific Demethylase 1A (LSD1
Chromosome	1p36.22
Protein Family	LSD1 family (Flavin-dependent amine oxidase)
Function	is a crucial epigenetic regulator that catalyzes the removal of methyl groups from histone lysine residues.
Pathways	Ferroptosis, bone metabolism, epigenetic regulation
UniProt ID	O60341
NCBI Gene ID	23028
Ensembl ID	ENSG00000136867
OMIM	607042
GeneCards	KDM1A
Human Protein Atlas	KDM1A
H3K4me1/2	Primary repressive target — removal activates gene expression
H3K9me1/2	Primary activating target — removal represses gene expression
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Neurodevelopmental Disorders
Interactions	EP300, FERROPTOSIS, HDAC2, KDM6A, SLC7A11
KG Connections	21 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KDM1A — AlphaFold O60341 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KDM1A (Lysine Specific Demethylase 1A)

gene · 931 words

→

KDM1A Protein (Lysine Specific Demethylase 1A (LSD1))

protein · 607 words

→

Pathway Diagram

graph TD
    KDM1A["KDM1A"]
    Cancer{"Cancer"}
    KDM1A -->|"regulates"| Cancer
    Tumor{"Tumor"}
    KDM1A -->|"inhibits"| Tumor
    Aging{"Aging"}
    KDM1A -->|"therapeutic target"| Aging
    Ms{"Ms"}
    KDM1A -->|"therapeutic target"| Ms
    CANCER["CANCER"]
    KDM1A -->|"regulates"| CANCER
    SLC7A11["SLC7A11"]
    KDM1A -->|"activates"| SLC7A11
    FERROPTOSIS["FERROPTOSIS"]
    KDM1A -->|"activates"| FERROPTOSIS
    Ferroptosis(["Ferroptosis"])
    KDM1A -->|"activates"| Ferroptosis
    HDAC2["HDAC2"]
    KDM1A -->|"inhibits"| HDAC2
    DNMT1["DNMT1"]
    KDM1A -->|"therapeutic target"| DNMT1
    EHMT2["EHMT2"]
    KDM1A -->|"therapeutic target"| EHMT2
    EP300["EP300"]
    KDM1A -->|"inhibits"| EP300
    style KDM1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
bone metabolism	regulates	process	0.70
Cancer	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
EP300	inhibits	gene	0.60
CANCER	regulates	gene	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
AMPK	therapeutic_target	gene	0.60
Notch	therapeutic_target	pathway	0.60
SLC7A11	activates	gene	0.60
HDAC2	inhibits	gene	0.60
DNMT1	therapeutic_target	gene	0.60
EHMT2	therapeutic_target	gene	0.60
Epigenetic	inhibits	pathway	0.60
Insulin Signaling	therapeutic_target	pathway	0.60
KDM6A	activates	gene	0.55
epigenetic regulation	participates_in	pathway	0.55

Incoming (2)

Source	Relation	Type	Str
ATBC	binds_to	drug	0.80
KDM6A	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KDM1A in their description or question text

No additional research found