gene

ABI3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABI3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

128Connections

1Hypotheses

0Analyses

50Outgoing

49Incoming

0Experiments

0Debates

Summary

A gene referenced in 107 knowledge graph relationships. Key connections: provides_data_for ds-83b31ef18d49 (dataset); provides_data_for ds-f50762b67605 (dataset); data_in ds-83b31ef18d49 (dataset).

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🧬 Gene Info

Gene Symbol	ABI3
Full Name	ABI Family Member 3 (Abl Interactor 3)
Aliases	Abl Interactor 3, ABI3 protein
Chromosome	17q21.31
Function	is a gene located on chromosome 17q21.
Molecular Weight	52 kDa
Amino Acids	360 aa
UniProt ID	Q9NZU7
NCBI Gene ID	10027
Ensembl ID	ENSG00000108506
OMIM	609469
GeneCards	ABI3
Human Protein Atlas	ABI3
Associated Diseases	ALZHEIMER'S DISEASE, DEMENTIA
Interactions	Actin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, COMPLEMENT, LRP1
KG Connections	107 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ABI3 Gene

gene · 2041 words

→

ABI3 Protein

protein · 832 words

→

Pathway Diagram

flowchart TD
    A["ABI3"] --> B["Microglia Activation"]
    A --> C["TREM2 Signaling"]
    B --> D["Phagocytosis"]
    C --> D
    D --> E["Amyloid Clearance"]
    D --> F["Synaptic Pruning"]
    E --> G["Neuroprotection"]
    F --> H["Neural Circuit Remodeling"]
    G --> I["Reduced AD Pathology"]
    C --> J["PI3K/AKT Pathway"]

Outgoing (79)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ABI3	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:ABI3	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
Alzheimer	activates	disease	0.65
Cancer	regulates	disease	0.65
ALZHEIMER'S DISEASE	increases_risk	disease	0.65
MICROGLIA	increases_risk	cell_type	0.65
DEMENTIA	interacts_with	disease	0.65
DEMENTIA	increases_risk	disease	0.65
NEUROINFLAMMATION	interacts_with	phenotype	0.65
Alzheimer	regulates	disease	0.65
Neuron	activates	cell_type	0.60
Innate Immunity	regulates	pathway	0.60
PTK2B	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
TREM2	regulates	gene	0.60
PLCG2	regulates	gene	0.60
phagocytosis	implicated_in	process	0.60
SIGLEC11	implicated_in	gene	0.60
CTSB	expressed_in	gene	0.60
MS4A6A	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Microglia	associated_with	cell_type	0.60
AMYLOID	activates	gene	0.60
microglia	expressed_in	cell_type	0.60
PICALM	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
Phagocytosis	associated_with	pathway	0.60
Amyloid	activates	pathway	0.60
CANCER	regulates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
Actin	activates	protein	0.60
COMPLEMENT	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Rb	associated_with	protein	0.60
PHAGOCYTOSIS	associated_with	entity	0.60
Complement	activates	pathway	0.60
TAU	activates	gene	0.60
LRP1	activates	gene	0.60
ABCA1	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
ACE	associated_with	gene	0.60

Incoming (49)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ABI3	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:ABI3	data_in	dataset_row	0.00
ds-f50762b67605	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
genes-abi3	describes	wiki	0.95
ALZHEIMER DISEASE	associated_with	gene	0.80
ADAM17	associated_with	gene	0.60
GRN	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
CLU	associated_with	gene	0.60
APP	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CD33	associated_with	gene	0.60
LRP1	activates	gene	0.60
SPI1	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
CTSB	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
EED	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
AMYLOID	activates	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NBR1	regulates	gene	0.60
CTSH	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CR1	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
ACE	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
CD33	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
PHAGOCYTOSIS	associated_with	gene	0.50
APOE	associated_with	gene	0.50
ABCA1	associated_with	gene	0.50
PLCG2	associated_with	gene	0.50
CORTEX	associated_with	brain_region	0.45
FRONTAL CORTEX	associated_with	brain_region	0.45
WHITE MATTER	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
CEREBELLUM	associated_with	brain_region	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD	0.620	Alzheimer's disease	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ABI3 in their description or question text

No additional research found