gene

HLA-DRB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HLA-DRB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

10Outgoing

8Incoming

0Experiments

0Debates

Summary

Page for HLA-DRB1 — MHC Class II DR Beta 1

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🧬 Gene Info

Gene Symbol	HLA
Primary Expression	Ca1, Cortex
Pathways	Jak-Stat, Apoptosis, Necroptosis, Epigenetic, Immune Response
GeneCards	HLA
Human Protein Atlas	HLA
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cardiovascular
Interactions	ABCA7, AGER, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE
KG Connections	296 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HLA_DRB1["HLA-DRB1"]
    PICALM["PICALM"]
    HLA_DRB1 -->|"expressed_in"| PICALM
    EPHA1["EPHA1"]
    HLA_DRB1 -->|"expressed_in"| EPHA1
    SORL1["SORL1"]
    HLA_DRB1 -->|"expressed_in"| SORL1
    BIN1["BIN1"]
    HLA_DRB1 -->|"expressed_in"| BIN1
    CD2AP("CD2AP")
    HLA_DRB1 -->|"expressed_in"| CD2AP
    Genes["Genes"]
    HLA_DRB1 -->|"expressed_in"| Genes
    IMMUNE_RESPONSE(["IMMUNE RESPONSE"])
    HLA_DRB1 -->|"expressed_in"| IMMUNE_RESPONSE
    Endocytosis(["Endocytosis"])
    HLA_DRB1 -->|"expressed_in"| Endocytosis
    Proteins("Proteins")
    HLA_DRB1 -->|"expressed_in"| Proteins
    CD33["CD33"]
    CD33 -->|"expressed_in"| HLA_DRB1
    late{"late"}
    late -->|"expressed_in"| HLA_DRB1
    ABCA7["ABCA7"]
    ABCA7 -->|"expressed_in"| HLA_DRB1
    microglia["microglia"]
    microglia -->|"expressed_in"| HLA_DRB1

Outgoing (10)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
PICALM	associated_with	gene	0.60
SORL1	expressed_in	gene	0.50
BIN1	expressed_in	gene	0.50
CD2AP	expressed_in	protein	0.50
PICALM	expressed_in	gene	0.50
Endocytosis	expressed_in	pathway	0.50
Proteins	expressed_in	protein	0.50
IMMUNE RESPONSE	expressed_in	pathway	0.50
EPHA1	expressed_in	gene	0.50

Incoming (8)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
CD33	associated_with	gene	0.60
CLU	associated_with	gene	0.60
endocytosis	associated_with	process	0.60
CD33	expressed_in	gene	0.50
late	expressed_in	disease	0.50
ABCA7	expressed_in	gene	0.50
microglia	expressed_in	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HLA-DRB1 in their description or question text

No additional research found