Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCN9A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SCN9A |
| Aliases | Nav1.7 |
| Function | Nav1.7 channels are voltage-gated sodium channels that mediate the rapid depolarization phase of action potentials in excitable cells. |
| Primary Expression | Highly expressed in peripheral sensory neurons (dorsal root ganglia, trigeminal ganglia), olfactory epithelium, and sympathetic neurons |
| Ensembl ID | ENSG00000169432 |
| GeneCards | SCN9A |
| Human Protein Atlas | SCN9A |
| Channel Structure | Alpha subunit consisting of four homologous domains (I-IV), each with six transmembrane segments (S1-S6) |
| Voltage Sensing | S1-S4 segments form the voltage sensor domain that detects membrane depolarization |
| Permeation | Segments S5-S6 form the pore domain that selects for sodium ions |
| Physiological Role | Critical for action potential initiation in nociceptors, contributing to pain perception and olfactory signal transduction |
| Inherited Erythromelalgia (IEM) | Gain-of-function mutations cause episodic pain attacks in extremities, typically triggered by warmth or exercise |
| Paroxysmal Extreme Pain Disorder (PEPD) | Mutations cause severe rectal or ocular pain episodes |
| Primary Erythromelalgia | Chronic burning pain syndrome |
| Alzheimer's Disease | Altered sodium channel expression may contribute to neuronal hyperexcitability; Nav1.7 upregulation observed in AD brain tissue |
| Associated Diseases | neurodegeneration |
| Interactions | NRF2 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SCN9A(["SCN9A"])
style SCN9A fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
neurons["neurons"]
neurodegeneration["neurodegeneration"]
SCN9A -->|"expressed_in"| neurons
SCN9A -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class neurons mechanism
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| Nociceptive Transmission | promotes | process | 0.91 |
| Endocytosis | involved_in | process | 0.88 |
| neurons | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SCN9A in their description or question text
No additional research found