gene

CLN5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLN5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

28Outgoing

10Incoming

0Experiments

0Debates

Summary

Page for CLN5 Gene - Ceroid Lipofuscinosis, Neuronal 5

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🧬 Gene Info

Gene Symbol	CLN5
Aliases	Page for CLN5 Gene
Chromosome	13q22.3
Protein Family	CLN5 family
Function	It contains a signal peptide for secretion and is targeted to lysosomes via mannose-6-phosphate-independent pathways[2].
Molecular Weight	48 kDa
Amino Acids	407 aa
Exons	4
Pathways	Autophagy
UniProt ID	Q9NWW5
NCBI Gene ID	1203
Ensembl ID	ENSG00000157540
OMIM	608096
GeneCards	CLN5
Human Protein Atlas	CLN5
Associated Diseases	neurodegeneration
Interactions	AUTOPHAGY, C1R, C1S, CR1, CTSH, PARP1
KG Connections	38 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLN5 — AlphaFold Q9NWW5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CLN5 Gene - Ceroid Lipofuscinosis, Neuronal 5

gene · 680 words

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CLN5 Protein

protein · 671 words

→

Pathway Diagram

graph TD
    CLN5["CLN5"]
    Ms{"Ms"}
    CLN5 -->|"regulates"| Ms
    Als{"Als"}
    CLN5 -->|"expressed_in"| Als
    CTSD["CTSD"]
    CLN5 -->|"regulates"| CTSD
    MICROTUBULES["MICROTUBULES"]
    CLN5 -->|"regulates"| MICROTUBULES
    ATG9["ATG9"]
    CLN5 -->|"associated_with"| ATG9
    AUTOPHAGY["AUTOPHAGY"]
    CLN5 -->|"activates"| AUTOPHAGY
    Autophagy(["Autophagy"])
    CLN5 -->|"activates"| Autophagy
    Exocytosis(["Exocytosis"])
    CLN5 -->|"associated_with"| Exocytosis
    LYST["LYST"]
    LYST -->|"regulates"| CLN5
    ATG1["ATG1"]
    ATG1 -->|"associated_with"| CLN5
    AND["AND"]
    AND -->|"regulates"| CLN5
    ATG5["ATG5"]
    ATG5 -->|"associated_with"| CLN5
    neurodegeneration["neurodegeneration"]
    CLN5 -->|"implicated_in"| neurodegeneration

Outgoing (28)

Target	Relation	Type	Str
SIRPA	interacts_with	gene	0.70
Ms	regulates	disease	0.65
Als	expressed_in	disease	0.65
AUTOPHAGY	activates	gene	0.60
MICROTUBULES	regulates	gene	0.60
Exocytosis	associated_with	pathway	0.60
Autophagy	activates	pathway	0.60
ATG9	associated_with	gene	0.60
CTSD	regulates	gene	0.60
Parkinson's disease	interacts_with	disease	0.60
ALS	interacts_with	disease	0.60
multiple sclerosis	interacts_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
blood-brain barrier	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
oligodendrocytes	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
CR1	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
SIGLEC9	interacts_with	gene	0.60
TPP1	interacts_with	gene	0.60
VEGFB	interacts_with	gene	0.60
CTSH	associated_with	gene	0.60
SIRPA	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
CTSH	interacts_with	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
TMEM106B	interacts_with	gene	0.60

Incoming (10)

Source	Relation	Type	Str
genes-cln5	describes	wiki_page	1.00
genes-cln5	documents	wiki_page	1.00
TMEM106B	interacts_with	gene	0.65
TMEM106B	increases_risk	gene	0.65
AND	regulates	gene	0.60
LYST	regulates	gene	0.60
ATG1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
C1R	interacts_with	gene	0.60
C1S	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLN5 in their description or question text

No additional research found