gene

SIGLEC9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIGLEC9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

29Outgoing

15Incoming

0Experiments

0Debates

Summary

Page for SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

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🧬 Gene Info

Gene Symbol	SIGLEC9
Full Name	Sialic Acid Binding Ig-Like Lectin 9
Chromosome	19q13.4
Function	is a member of the CD33-related Siglec family of inhibitory lectins.
Primary Expression	Neutrophils, monocytes, NK cells, B cells
Molecular Weight	55 kDa
Amino Acids	482 aa
Exons	11
UniProt ID	Q9Y736
NCBI Gene ID	27180
GeneCards	SIGLEC9
Human Protein Atlas	SIGLEC9
Associated Diseases	ALS, Alzheimer's disease, Parkinson's disease, Tumor
Interactions	C1R, C1S, CLN5, CR1, PARP1, SIRPA
KG Connections	44 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SIGLEC9 — AlphaFold Q9Y736 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

gene · 2748 words

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SIGLEC9 Protein

protein · 2432 words

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Pathway Diagram

graph TD
    SIGLEC9["SIGLEC9"]
    Alzheimer{"Alzheimer"}
    SIGLEC9 -->|"therapeutic target"| Alzheimer
    Ms{"Ms"}
    SIGLEC9 -->|"therapeutic target"| Ms
    Dementia{"Dementia"}
    SIGLEC9 -->|"therapeutic target"| Dementia
    Als{"Als"}
    SIGLEC9 -->|"therapeutic target"| Als
    Tumor{"Tumor"}
    SIGLEC9 -->|"associated with"| Tumor
    Glioblastoma{"Glioblastoma"}
    SIGLEC9 -->|"therapeutic target"| Glioblastoma
    SIRPA["SIRPA"]
    SIGLEC9 -->|"associated with"| SIRPA
    GRN["GRN"]
    SIGLEC9 -->|"associated with"| GRN
    GBM["GBM"]
    SIGLEC9 -->|"therapeutic target"| GBM
    neurodegeneration["neurodegeneration"]
    SIGLEC9 -->|"implicated in"| neurodegeneration
    TREM2["TREM2"]
    TREM2 -->|"associated with"| SIGLEC9
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| SIGLEC9
    CTSH["CTSH"]
    CTSH -->|"associated with"| SIGLEC9
    TMEM106B["TMEM106B"]
    TMEM106B -->|"associated with"| SIGLEC9
    CD4["CD4"]
    CD4 -->|"therapeutic target"| SIGLEC9
    style SIGLEC9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.70
Tumor	associated_with	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
TPP1	interacts_with	gene	0.60
VEGFB	interacts_with	gene	0.60
SIRPA	interacts_with	gene	0.60
SIRPA	associated_with	gene	0.60
GRN	associated_with	gene	0.60
multiple sclerosis	interacts_with	disease	0.60
blood-brain barrier	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
oligodendrocytes	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
Alzheimer's disease	causes	disease	0.60
Parkinson's disease	causes	disease	0.60
ALS	causes	disease	0.60
GBM	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
Parkinson's disease	interacts_with	disease	0.60
ALS	interacts_with	disease	0.60
TMEM106B	associated_with	gene	0.60
CTSH	associated_with	gene	0.60

Incoming (15)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
CD4	therapeutic_target	gene	0.60
TREM2	associated_with	gene	0.60
CTSH	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
C1R	interacts_with	gene	0.60
C1S	interacts_with	gene	0.60
CLN5	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
ADAM15	causes	gene	0.60
CD33	causes	gene	0.60
CD38	causes	gene	0.60
GPNMB	causes	gene	0.60
GRN	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SIGLEC9 in their description or question text

No additional research found