concept

UBIQUITINATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBIQUITINATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

2Hypotheses

0Analyses

30Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	UBIQUITINATION
Key Genes/Proteins	UBIQUITIN, UBIQUITIN_LIGASES, USP7
Related Pathways	DIA_MS

Pathway Diagram

graph TD
    UBIQUITINATION["UBIQUITINATION"]
    UBIQUITINATION -->|"modulates"| G3BP1["G3BP1"]
    UBIQUITINATION -->|"regulates"| Protein_Stability["Protein Stability"]
    UBIQUITINATION -->|"mediates"| NLRP3["NLRP3"]
    UBIQUITINATION -->|"modulates"| TDP_43["TDP-43"]
    UBIQUITINATION -->|"regulates"| ATG5["ATG5"]
    UBIQUITINATION -->|"involved_in"| NLRP3_Autophagy_Degradation["NLRP3 Autophagy Degradation"]
    USP7["USP7"] -->|"regulates"| UBIQUITINATION
    PEDV_N["PEDV N"] -->|"involved_in"| UBIQUITINATION
    ubiquitin_ligases["ubiquitin ligases"] -->|"activates"| UBIQUITINATION
    deubiquitinases["deubiquitinases"] -->|"inhibits"| UBIQUITINATION
    MARCH2["MARCH2"] -->|"regulates"| UBIQUITINATION
    UBIQUITIN_LIGASES["UBIQUITIN LIGASES"] -->|"catalyzes"| UBIQUITINATION
    __SYNUCLEIN["Alpha-SYNUCLEIN"] -->|"involved_in"| UBIQUITINATION
    DUBS["DUBS"] -->|"regulates"| UBIQUITINATION

Outgoing (30)

Target	Relation	Type	Str
Protein Stability	regulates	process	0.95
G3BP1	modulates	protein	0.95
G3BP1	modulates	entity	0.95
G3BP1	regulates	protein	0.90
Autophagy	interacts_with	process	0.90
TARDBP	promotes	protein	0.90
Pedv Infection	involved_in	disease	0.85
TDP-43	modulates	protein	0.85
ATG5	regulates	protein	0.85
breast cancer	associated_with	disease	0.85
NLRP3 Autophagy Degradation	involved_in	process	0.85
NLRP3	regulates	protein	0.85
NLRP3	mediates	protein	0.85
NF-κB Pathway Activation	regulates	process	0.85
xenophagy	regulates	pathway	0.80
NLRP3 Inflammasome Activation	regulates	process	0.80
protein_localization	regulates	biological_process	0.80
protein_metabolism	regulates	biological_process	0.80
protein_degradation	regulates	biological_process	0.80
cellular_physiological_processes	regulates	biological_process	0.80
NLRP3	modulates	protein	0.80
Plin2 Stability	regulates	molecular_function	0.80
Nlrp3 Inflammasome	regulates	protein	0.80
PTEN	inhibits	gene	0.80
Protein Degradation	involved_in	process	0.70
PTEN	regulates	gene	0.70
PEDV_N_protein	regulates	protein	0.64
USP7	regulates	gene	0.60
USP7	inhibits	gene	0.60
VCP	activates	gene	0.60

Incoming (69)

Source	Relation	Type	Str
TARDBP	involved_in	protein	0.95
SPOP	mediates	protein	0.95
MARCH2	regulates	protein	0.90
UBIQUITIN LIGASES	catalyzes	enzyme	0.90
ubiquitin ligases	activates	protein	0.90
deubiquitinases	inhibits	protein	0.90
Tardbp	associated_with	protein	0.90
PEDV N	involved_in	protein	0.90
PRKN	mediates	protein	0.90
LRP1	mediates	protein	0.85
Α-SYNUCLEIN	involved_in	protein	0.85
RAB7A	inhibits	protein	0.85
L1-70 FRAGMENT	substrate_of	protein	0.80
AIMP2-DX2	inhibits	protein	0.80
SLC25A3	associated_with	protein	0.80
GPX4	substrate_of	protein	0.80
selective autophagy	promotes	process	0.80
macroautophagy	interacts_with	process	0.75
USP7	regulates	protein	0.72
UBIQUITIN	participates_in	protein	0.72
MARCHF8	catalyzes	protein	0.72
α-synuclein	undergoes	protein	0.70
UBIQUITIN_LIGASES	catalyzes	protein	0.64
circMTCL1	inhibits	protein	0.64
autophagy	activates	pathway	0.60
LRP1	associated_with	gene	0.60
LRP1	regulates	gene	0.60
STX17	regulates	gene	0.60
TGM2	activates	gene	0.60
MIRO1	binds_to	gene	0.60
PARKIN	binds_to	gene	0.60
MYC	binds_to	gene	0.60
NLRP3	activates	gene	0.60
G3BP1	associated_with	gene	0.60
G3BP1	regulates	gene	0.60
autophagy	regulates	pathway	0.60
RNA	activates	gene	0.60
mitophagy	activates	pathway	0.60
necroptosis	activates	pathway	0.60
GPX4	activates	gene	0.60
GPX4	inhibits	gene	0.60
TRIM25	inhibits	gene	0.60
RAB7A	activates	gene	0.60
autophagy	inhibits	pathway	0.60
RIPK1	activates	gene	0.60
MTOR	activates	gene	0.60
TAK1	activates	gene	0.60
PARKIN	activates	gene	0.60
CAV1	regulates	gene	0.60
PARKIN	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CHIP-mediated ubiquitination selectively targets oligomeric	0.580	protein biochemistry	Do chaperones selectively recognize path
TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gr	0.548	neurodegeneration	What determines the spatial organization

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TRIM21 E3 ubiquitin ligase screen for stress granule regulation	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBIQUITINATION in their description or question text

No additional research found