gene 898 words KG: USP7
Contents

USP7 Gene

🧬 Gene Info
Gene SymbolUSP7
Full NameUbiquitin-Specific Peptidase 7
AliasesHAUSP Deubiquitinase
Chromosome16p13.2
Protein TypeEnzyme
Functionencodes a deubiquitinating enzyme (DUB) that removes ubiquitin from target proteins, regulating their stability and function.
Molecular Weight128 kDa
Amino Acids102 aa
PathwaysNF-κB, Wnt signaling
UniProt IDQ93009
NCBI Gene ID7874
Ensembl IDENSG00000187555
OMIM602519
GeneCardsUSP7
Human Protein AtlasUSP7
Associated DiseasesAls, Cancer, glioblastoma, Huntington's disease
Known Drugs/CompoundsH2O2
InteractionsALOX15, AMBRA1, AND, AR, ATM, CANCER
KG Connections157 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: associated_with
Exosomes
entity · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: stabilizes
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: inhibits
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activates

Knowledge Graph (12 edges)

USP7 inhibits PROTEIN_DEGRADATION
USP7 inhibits HNRNPA1
USP7 inhibits ALOX15
MLKL regulates USP7
USP7 modifies AMBRA1
H2O2 activates USP7
HNRNPA1 inhibits USP7
ALOX15 inhibits USP7
YY1 interacts_with USP7
USP7 activates AMBRA1

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