concept

USP13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USP13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

14Outgoing

15Incoming

0Experiments

0Debates

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💡 Concept Info

Name	USP13
Key Genes/Proteins	ATG5, BECN1, BMAL1, BRCC3, CYLD, KRAS
Related Diseases	blood-brain barrier dysfunction, Blood-Brain Barrier Dysfunction, cancer
Related Pathways	autophagy pathway, blood-brain barrier, ferroptosis

Wiki Pages (2)

Knowledge base pages for this entity

USP13 Inhibitor for Mitophagy and Synaptic Proteostasis

idea · 1974 words

→

USP13 Deubiquitinase Inhibition for Parkin-Independent Mitophagy Rescue

idea · 1603 words

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Pathway Diagram

graph TD
    USP13[USP13]
    USP13 -->|regulates| USP7[USP7]
    USP13 -->|regulates| cancer[cancer]
    USP13 -->|participates in| ferroptosis[ferroptosis]
    USP13 -->|interacts| USP14[USP14]
    USP13 -->|interacts| USP25[USP25]
    USP13 -->|participates in| ubiquitin_proteasome[ubiquitin-proteasome]
    USP13 -->|activates| VPS34[VPS34]
    USP13 -->|participates in| autophagy_pathway[autophagy pathway]
    USP13 -->|participates in| blood_brain_barrier[blood-brain barrier]
    Spautin_1[Spautin-1] -->|inhibits| USP13
    OTUD3[OTUD3] -->|regulates| USP13
    PTEN[PTEN] -->|regulates| USP13
    BECN1[BECN1] -->|activates| USP13
    PIK3C3[PIK3C3] -->|activates| USP13
    NFE2L2[NFE2L2] -->|interacts| USP13
    BMAL1[BMAL1] -->|activates| USP13
    BRCC3[BRCC3] -->|interacts| USP13
    CYLD[CYLD] -->|interacts| USP13
    ATG5[ATG5] -->|activates| USP13

Outgoing (14)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:USP13	data_in	dataset_row	0.00
Blood-Brain Barrier Dysfunction	associated_with	phenotype	0.85
blood-brain barrier dysfunction	associated_with	phenotype	0.75
blood-brain barrier	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
VPS34	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
USP14	interacts_with	gene	0.60
USP25	interacts_with	gene	0.60
USP7	regulates	gene	0.60
cancer	regulates	disease	0.60
cancer	interacts_with	disease	0.60
ferroptosis	participates_in	pathway	0.60

Incoming (15)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:USP13	data_in	dataset_row	0.00
Spautin-1	inhibits	compound	0.95
BMAL1	targets	gene	0.65
BMAL1	activates	gene	0.60
BRCC3	interacts_with	gene	0.60
USP11	regulates	gene	0.60
OTUD3	regulates	gene	0.60
PTEN	regulates	gene	0.60
BECN1	activates	gene	0.60
PIK3C3	activates	gene	0.60
NFE2L2	interacts_with	gene	0.60
ATG5	activates	gene	0.60
PAK1	activates	gene	0.60
KRAS	interacts_with	gene	0.60
CYLD	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning USP13 in their description or question text

No additional research found