Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRANSFERRIN RECEPTOR 2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TRANSFERRIN RECEPTOR 2 |
| Amino Acids | 801 aa |
| Pathways | MAPK pathway |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
flowchart TD
TRANSFERRIN_RECEPTOR_2["TRANSFERRIN RECEPTOR 2"]
TRANSFERRIN["TRANSFERRIN"]
IRON_METABOLISM["IRON METABOLISM"]
HEMOCHROMATOSIS["HEMOCHROMATOSIS"]
HEPATOCYTE["HEPATOCYTE"]
ERYTHROID_PRECURSOR["ERYTHROID PRECURSOR"]
ERYTHROPOIESIS["ERYTHROPOIESIS"]
IRON_TRANSPORT["IRON TRANSPORT"]
TRANSFERRIN_RECEPTOR_2 -->|"binds to"| TRANSFERRIN
TRANSFERRIN_RECEPTOR_2 -->|"involved in"| IRON_METABOLISM
TRANSFERRIN_RECEPTOR_2 -->|"associated with"| HEMOCHROMATOSIS
TRANSFERRIN_RECEPTOR_2 -->|"expressed in"| HEPATOCYTE
TRANSFERRIN_RECEPTOR_2 -->|"expressed in"| ERYTHROID_PRECURSOR
TRANSFERRIN_RECEPTOR_2 -->|"regulates"| ERYTHROPOIESIS
TRANSFERRIN_RECEPTOR_2 -->|"involved in"| IRON_TRANSPORT
style TRANSFERRIN_RECEPTOR_2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| HEMOCHROMATOSIS | associated_with | entity | 0.90 |
| HEPATOCYTE | expressed_in | entity | 0.90 |
| ERYTHROID PRECURSOR | expressed_in | entity | 0.90 |
| Transferrin | binds | protein | 0.90 |
| TRANSFERRIN | binds_to | entity | 0.90 |
| IRON METABOLISM | involved_in | entity | 0.90 |
| ERYTHROPOIESIS | regulates | entity | 0.85 |
| IRON TRANSPORT | involved_in | entity | 0.85 |
| Erythropoietin Receptor | forms_complex_with | protein | 0.80 |
| Hepcidin | regulates | protein | 0.80 |
| Iron | transports | chemical | 0.80 |
| Hemochromatosis Protein | forms_complex_with | protein | 0.80 |
| TFR1 | references | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TRANSFERRIN RECEPTOR 2 in their description or question text
No additional research found