protein

SORTILIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SORTILIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

22Outgoing

14Incoming

0Experiments

0Debates

Summary

Page for Sortilin Protein

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🔬 Protein Info

Gene Symbol	SORTILIN
Function	Sortilin is a member of the vacuolar protein sorting 10 (VPS10) domain receptor family that functions as a multifunctional sorting receptor involved in intracellular trafficking, protein degradatio...
Molecular Weight	100 kDa
Amino Acids	600 aa
Pathways	Neurotrophic Signaling, Synaptic Plasticity
GeneCards	SORTILIN
Human Protein Atlas	SORTILIN
Associated Diseases	Alzheimer'S Disease, disease
Interactions	BDNF, IGF2R, TRANSFERRIN
KG Connections	34 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    SORTILIN["SORTILIN"]
    INSULIN["INSULIN"]
    SORTILIN -->|"interacts_with"| INSULIN
    SORCS1(["SORCS1"])
    SORTILIN -->|"associated_with"| SORCS1
    ENDOSOME["ENDOSOME"]
    SORTILIN -->|"interacts_with"| ENDOSOME
    ALZHEIMER(["ALZHEIMER"])
    SORTILIN -->|"associated_with"| ALZHEIMER
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    SORTILIN -->|"associated_with"| Alzheimer_S_Disease
    disease{"disease"}
    SORTILIN -->|"associated_with"| disease
    TRANSFERRIN(["TRANSFERRIN"])
    TRANSFERRIN -->|"interacts_with"| SORTILIN
    IGF2R(["IGF2R"])
    IGF2R -->|"interacts_with"| SORTILIN
    SORCS2(["SORCS2"])
    SORCS2 -->|"associated_with"| SORTILIN
    SORCS3(["SORCS3"])
    SORCS3 -->|"associated_with"| SORTILIN
    style SORTILIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (22)

Target	Relation	Type	Str
BDNF	regulates	protein	0.90
Trk Receptors	regulates	protein	0.88
Neurotrophic Signaling	modulates	pathway	0.85
Proneurotrophins	mediates	protein	0.85
BDNF	transports	protein	0.85
NEURON	expressed_in	cell_type	0.80
INSULIN	interacts_with	concept	0.50
SORCS1	associated_with	protein	0.50
ENDOSOME	interacts_with	concept	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
SORCS1	regulates	protein	0.50
SYNAPSE	regulates	concept	0.50
ALZHEIMER	causes	gene	0.50
Alzheimer'S Disease	causes	disease	0.50
disease	causes	disease	0.50
ALZHEIMER'S	causes	concept	0.50
Synaptic Plasticity	inhibits	pathway	0.50
disease	inhibits	disease	0.50
NEURONS	inhibits	concept	0.50

Incoming (14)

Source	Relation	Type	Str
entities-al001	interacts_with	wiki	0.00
TDP-43	regulates_splicing_of	protein	0.90
PROBDNF	activates	protein	0.80
TRANSFERRIN	interacts_with	protein	0.50
IGF2R	interacts_with	protein	0.50
SORCS2	associated_with	gene	0.50
SORCS3	associated_with	gene	0.50
SORCS2	regulates	gene	0.50
SORCS3	regulates	gene	0.50
SORL1	regulates	gene	0.50
BDNF	regulates	gene	0.50
SORL1	causes	gene	0.50
BDNF	inhibits	gene	0.50
Tdp-43	inhibits	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SORTILIN in their description or question text

No additional research found