protein

HEPCIDIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEPCIDIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

1Hypotheses

1Analyses

12Outgoing

11Incoming

0Experiments

1Debates

Summary

Page for Hepcidin

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🔬 Protein Info

Gene Symbol	HEPCIDIN
Function	Hepcidin is the master regulator of systemic iron homeostasis and a key hormone that controls iron absorption, recycling, and distribution throughout the body.
Pathways	Reactive Oxygen Species
GeneCards	HEPCIDIN
Human Protein Atlas	HEPCIDIN
Interactions	FERROPORTIN, TRANSFERRIN
KG Connections	16 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    HEPCIDIN["HEPCIDIN"]
    HEPCIDIN -->|"inhibits"| Ferroportin["Ferroportin"]
    HEPCIDIN -->|"regulates"| FERROPORTIN["FERROPORTIN"]
    HEPCIDIN -->|"regulates"| IRON_METABOLISM["IRON METABOLISM"]
    HEPCIDIN -->|"regulates"| SLC40A1["SLC40A1"]
    HEPCIDIN -->|"regulates"| FERRITINH["FERRITINH"]
    HEPCIDIN -->|"activates"| HEPATOCYTES["HEPATOCYTES"]
    HEPCIDIN -->|"regulates"| CYTOKINES["CYTOKINES"]
    Iron_Load["Iron Load"] -->|"upregulates"| HEPCIDIN
    TFR2["TFR2"] -->|"regulates"| HEPCIDIN
    TRANSFERRIN["TRANSFERRIN"] -->|"interacts"| HEPCIDIN
    FERROPORTIN -->|"interacts"| HEPCIDIN
    APOE["APOE"] -->|"regulates"| HEPCIDIN
    TFR1["TFR1"] -->|"regulates"| HEPCIDIN
    GPX4["GPX4"] -->|"regulates"| HEPCIDIN
    MAP2["MAP2"] -->|"regulates"| HEPCIDIN

Outgoing (12)

Target	Relation	Type	Str
Ferroportin	inhibits	protein	0.95
FERROPORTIN	regulates	entity	0.95
IRON METABOLISM	regulates	entity	0.95
Ferroportin	downregulates	entity	0.93
SLC40A1	regulates	gene	0.90
iron_homeostasis	regulates	pathway	0.90
ferroportin	inhibits	protein	0.90
FERRITINH	regulates	protein	0.70
HEPATOCYTES	activates	concept	0.50
CYTOKINES	regulates	concept	0.50
Reactive Oxygen Species	regulates	process	0.50
Proteins	regulates	protein	0.50

Incoming (11)

Source	Relation	Type	Str
Iron Load	upregulates	phenotype	0.90
Transferrin Receptor 2	regulates	protein	0.80
REV-ERBα	regulates	protein	0.70
TRANSFERRIN	interacts_with	protein	0.50
FERROPORTIN	interacts_with	protein	0.50
APOE	regulates	gene	0.50
TFR1	regulates	gene	0.50
GPX4	regulates	gene	0.50
MAP2	regulates	gene	0.50
TRANSFERRIN	regulates	protein	0.50
FERROPORTIN	regulates	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hepcidin-Iron Set Point Hypothesis	0.577	endocrinology	Does TRT-induced erythrocytosis actually

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do circadian disruptions cause neurodegeneration or result from it?

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted that speech timing and sleep changes could reflect circad

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Related Research

Hypotheses and analyses mentioning HEPCIDIN in their description or question text

No additional research found