protein

HFE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HFE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

1Hypotheses

1Analyses

29Outgoing

12Incoming

0Experiments

1Debates

Summary

HFE is a protein involved in neurodegeneration research. Key relationships include: regulates, interacts with, expressed in. Associated with ALS, Als, Ischemia. Connected to 18 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HFE
Aliases	Page for HFE Protein
Chromosome	6p22.2
Function	The HFE gene encodes a 348-amino acid transmembrane protein that is structurally related to major histocompatibility complex (MHC) class I proteins
Primary Expression	various brain regions including cortex, hippocampus, basal ganglia
Molecular Weight	40 kDa
Amino Acids	348 aa
Pathways	Endocytosis
Ensembl ID	ENSG00000070010
GeneCards	HFE
Human Protein Atlas	HFE
Iron sensing	HFE protein forms a complex with beta-2-microglobulin and interacts with transferrin receptor 1 (TfR1), modulating cellular iron uptake.
Regulation of hepcidin	HFE regulates the expression of hepcidin, the key hormone controlling systemic iron homeostasis.
Intestinal iron absorption	By modulating hepcidin, HFE controls iron absorption in the duodenum.
Cellular iron metabolism	Influences intracellular iron levels through transferrin-mediated iron uptake.
Associated Diseases	Als
Interactions	CAT, GSK3, TFR1
KG Connections	41 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HFE Gene - Hereditary Hemochromatosis Protein

gene · 865 words

→

HFE Protein - Homeostatic Iron Regulator

protein · 883 words

→

Pathway Diagram

graph TD
    HFE["HFE"]
    Ischemia{"Ischemia"}
    HFE -->|"regulates"| Ischemia
    Ms{"Ms"}
    HFE -->|"interacts with"| Ms
    Als{"Als"}
    HFE -->|"regulates"| Als
    HFE -->|"associated with"| Als
    Tumor{"Tumor"}
    HFE -->|"interacts with"| Tumor
    ALS{"ALS"}
    HFE -->|"regulates"| ALS
    Endocytosis(["Endocytosis"])
    HFE -->|"regulates"| Endocytosis
    TFR1["TFR1"]
    HFE -->|"regulates"| TFR1
    JUN["JUN"]
    HFE -->|"regulates"| JUN
    MITOCHONDRIA["MITOCHONDRIA"]
    HFE -->|"regulates"| MITOCHONDRIA
    Neuron["Neuron"]
    HFE -->|"expressed in"| Neuron
    T_Cell["T Cell"]
    HFE -->|"expressed in"| T_Cell
    JUN -->|"regulates"| HFE
    TFR1 -->|"regulates"| HFE
    CAT["CAT"]
    CAT -->|"interacts with"| HFE
    TFR1 -->|"interacts with"| HFE
    MITOCHONDRIA -->|"regulates"| HFE
    AND["AND"]
    AND -->|"interacts with"| HFE
    style HFE fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:HFE	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Ms	interacts_with	disease	0.65
Als	regulates	disease	0.65
Ischemia	regulates	disease	0.65
Als	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
ALS	regulates	disease	0.65
Transferrin	regulates	protein	0.60
LRRK2	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
Endocytosis	regulates	pathway	0.60
Hepatocyte	interacts_with	cell_type	0.60
apoptosis pathway	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Parkinson's disease	activates	disease	0.60
Wnt signaling	participates_in	pathway	0.60
TFR1	regulates	gene	0.60
JUN	regulates	gene	0.60
Ferritin	regulates	protein	0.60
Neuron	regulates	cell_type	0.60
ALS	associated_with	disease	0.60
MITOCHONDRIA	regulates	gene	0.60
Dopaminergic	regulates	cell_type	0.60
T Cell	regulates	cell_type	0.60
Neuron	expressed_in	cell_type	0.55
T Cell	expressed_in	cell_type	0.55

Incoming (12)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:HFE	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
CAT	interacts_with	gene	0.60
TFR1	interacts_with	gene	0.60
DJ1	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
JUN	regulates	gene	0.60
C9ORF72	associated_with	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
GSK3	inhibits	gene	0.60
GBA1	associated_with	gene	0.60
TFR1	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
H63D HFE Genotype-Guided Iron Chelation Therapy for Subset-S	0.550	-	Ferroptosis in ALS and motor neuron dise

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows deferiprone rescues wild-type cells but exacerbates toxicity in

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning HFE in their description or question text

No additional research found