gene

PIK3CB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3CB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

45Outgoing

27Incoming

0Experiments

0Debates

Summary

PIK3CB is a gene implicated in neurodegeneration research. Key relationships include: expressed in, therapeutic target, associated with. Associated with Als, Cancer, Carcinoma. Connected to 60 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PIK3CB
Full Name	Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta
Chromosome	22q13.33
Function	is a major signaling cascade in neurons
Amino Acids	1048 aa
Pathways	PI3K, mTOR signaling
UniProt ID	Q14184
NCBI Gene ID	5293
Ensembl ID	ENSG00000077150
GeneCards	PIK3CB
Human Protein Atlas	PIK3CB
Associated Diseases	Als, Ms
KG Connections	72 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PIK3CB — AlphaFold Q14184 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PIK3CB — Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta

gene · 1512 words

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Pathway Diagram

graph TD
    PIK3CB["PIK3CB"]
    Als{"Als"}
    PIK3CB -->|"associated with"| Als
    Ms{"Ms"}
    PIK3CB -->|"associated with"| Ms
    Carcinoma{"Carcinoma"}
    PIK3CB -->|"therapeutic target"| Carcinoma
    Cancer{"Cancer"}
    PIK3CB -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    PIK3CB -->|"therapeutic target"| Tumor
    Cardiac{"Cardiac"}
    PIK3CB -->|"regulates"| Cardiac
    RALB["RALB"]
    PIK3CB -->|"expressed in"| RALB
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    PIK3CB -->|"associated with"| AUTOPHAGY_RELATED_GENES
    GNAI3["GNAI3"]
    PIK3CB -->|"expressed in"| GNAI3
    WIPI1["WIPI1"]
    PIK3CB -->|"expressed in"| WIPI1
    Autophagy(["Autophagy"])
    PIK3CB -->|"associated with"| Autophagy
    PIK3R1["PIK3R1"]
    PIK3CB -->|"therapeutic target"| PIK3R1
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| PIK3CB
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"expressed in"| PIK3CB
    CD8["CD8"]
    CD8 -->|"associated with"| PIK3CB
    LRRK2["LRRK2"]
    LRRK2 -->|"expressed in"| PIK3CB
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"associated with"| PIK3CB
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"associated with"| PIK3CB
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| PIK3CB
    GBA["GBA"]
    GBA -->|"expressed in"| PIK3CB
    WDFY3["WDFY3"]
    WDFY3 -->|"expressed in"| PIK3CB
    PIK3CA["PIK3CA"]
    PIK3CA -->|"therapeutic target"| PIK3CB
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| PIK3CB
    PIK3CD["PIK3CD"]
    PIK3CD -->|"therapeutic target"| PIK3CB
    style PIK3CB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PIK3CB	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Cardiac	regulates	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Gastric Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Invasion	expressed_in	pathway	0.60
Microrna	expressed_in	pathway	0.60
CANCER	expressed_in	gene	0.60
Angiogenesis	expressed_in	pathway	0.60
MICRORNAS	expressed_in	gene	0.60
Pi3K/Akt	expressed_in	pathway	0.60
Mtor	expressed_in	pathway	0.60
MMP2	associated_with	gene	0.60
HIP1R	regulates	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT3	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
PIK3CD	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
NOS1	regulates	gene	0.60
CFTR	regulates	gene	0.60
EPHB4	associated_with	gene	0.60
RALB	expressed_in	gene	0.60
GNAI3	expressed_in	gene	0.60
WIPI1	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
Akt	therapeutic_target	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
GENES	therapeutic_target	gene	0.60
TSC1	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60

Incoming (27)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PIK3CB	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
PI3K	expressed_in	gene	0.60
RYR2	regulates	gene	0.60
SCN1A	regulates	gene	0.60
ROBO1	associated_with	gene	0.60
GAD2	regulates	gene	0.60
MIRNAS	expressed_in	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
PIK3CD	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
PIK3R3	therapeutic_target	gene	0.60
AKT3	therapeutic_target	gene	0.60
MIRNAS	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
C9ORF72	expressed_in	gene	0.60
CD8	associated_with	gene	0.60
LRRK2	expressed_in	gene	0.60
GBA	expressed_in	gene	0.60
WDFY3	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PIK3CB in their description or question text

No additional research found