disease

FRONTOTEMPORAL DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRONTOTEMPORAL DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2167Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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Disease Info

Associated Genes	AD, AMYLOID, amyotrophic lateral sclerosis, APOE, ATXN2, C9ORF72, CHMP2B, CREB
KG Connections	805 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| STEM_CELLS["STEM CELLS"]
    style STEM_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| IPSC["IPSC"]
    style IPSC fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"interacts"| TDP_43["TDP-43"]
    style TDP_43 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"interacts"| NEURON["NEURON"]
    style NEURON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| ULK1["ULK1"]
    style ULK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| MITOCHONDRIA["MITOCHONDRIA"]
    style MITOCHONDRIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
    style RAPAMYCIN fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NEURODEGENERATION["NEURODEGENERATION"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    TARDBP["TARDBP"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style TARDBP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style FRONTOTEMPORAL_DEMENTIA fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (592)

Target	Relation	Type	Str
NEURON	interacts_with	cell_type	0.95
Behavioral Disturbances	causes	phenotype	0.95
Neurodegeneration	causes	process	0.95
Frontal Lobe Neurodegeneration	causes	process	0.95
Anterior Temporal Lobe Neurodegeneration	causes	process	0.95
STEM CELLS	activates	cell_type	0.95
TDP-43	interacts_with	gene	0.95
IPSC	activates	cell_type	0.95
neurons	affects	cell_type	0.90
cortex	affects	brain_region	0.90
neural stem cells	affects	cell_type	0.90
oxidative stress response	involves	pathway	0.90
Brain Atrophy	causes	phenotype	0.90
unfolded protein response	involves	pathway	0.90
Pre-Symptomatic Stage	associated_with	phenotype	0.90
Movement Disorders	associated_with	disease	0.85
Anterior Temporal Lobe	expressed_in	cell_type	0.85
TARDBP	associated_with	protein	0.85
MAPT	associated_with	gene	0.85
Frontal Lobe	expressed_in	cell_type	0.85
microglia	affects	cell_type	0.80
CRISPR-Cas	involves	pathway	0.80
endosome	disrupts	organelle	0.80
epigenetic regulation	involves	pathway	0.80
spinal cord	affects	brain_region	0.80
cerebellum	affects	brain_region	0.80
lipid metabolism	involves	pathway	0.80
NEURONS	associated_with	cell_type	0.80
TDP-43	regulates	gene	0.80
TAU	biomarker_for	gene	0.70
MAPT	interacts_with	gene	0.70
NRF2	interacts_with	gene	0.70
FTD	expressed_in	disease	0.70
MAPT	activates	gene	0.70
HTT	interacts_with	gene	0.70
OPTN	interacts_with	gene	0.70
LEWY BODY DEMENTIA	markers	disease	0.70
PROGRESSIVE SUPRANUCLEAR PALSY	regulates	disease	0.70
TAU	activates	gene	0.70
PSD95	interacts_with	gene	0.70
TREM2	activates	gene	0.70
NEURONS	disrupts	cell_type	0.70
PSEN1	associated_with	gene	0.70
VCP	associated_with	gene	0.70
TREM2	causes	gene	0.70
VCP	causes	gene	0.70
LRRK2	interacts_with	gene	0.70
GRN	associated_with	gene	0.70
LAMP1	inhibits	gene	0.70
MOTOR NEURON	expresses	cell_type	0.70

Incoming (1575)

Source	Relation	Type	Str
entities-glp1-receptor	associated_with	wiki	0.00
entities-microtubules	associated_with	wiki	0.00
ALS	activates	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
NEURODEGENERATIVE DISORDERS	part_of	gene	1.00
ALS	associated_with	disease	1.00
TARDBP	associated_with	gene	1.00
TAU	associated_with	protein	1.00
ALS	causes	disease	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
ALS	interacts_with	disease	0.98
SQSTM1	biomarker_for	protein	0.95
C9ORF72	associated_with	gene	0.95
Tau	biomarker_for	protein	0.95
GRN	risk_factor_for	gene	0.95
TBK1	associated_with	gene	0.95
Synaptic Dysfunction	contributes_to	phenotype	0.95
TDP-43	causes	protein	0.95
TDP43	associated_with	protein	0.95
MAPT	associated_with	gene	0.95
C9orf72 Hexanucleotide Repeat Expansion	causes	biomarker	0.95
TBK1	associated_with	gene	0.95
Cerebral Perfusion	biomarker_for	biomarker	0.92
Frontotemporal Phenotype	associated_with	phenotype	0.90
ALS	activates	gene	0.90
MAPT	associated_with	gene	0.90
FTLD	interacts_with	gene	0.90
CHMP2BIn5	drives	protein	0.90
Innate Immune Activation	associated_with	process	0.90
STING	associated_with	protein	0.90
C9ORF72	causes	gene	0.90
Cryptic Splicing	biomarker_for	process	0.90
FUS	associated_with	gene	0.90
FUS	associated_with	gene	0.90
ALS	expressed_in	gene	0.90
ALS	accumulates_in	gene	0.90
Tau Aggregation	associated_with	process	0.90
ALS	causes	gene	0.90
Neurodegeneration	involved_in	process	0.90
ALS	regulates	gene	0.90
SOD1	associated_with	gene	0.90
C9ORF72 Hexanucleotide Repeat Expansion	risk_factor_for	biomarker	0.90
TAU	associated_with	protein	0.90
Autophagy	involved_in	process	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
Tdp-43-Targeting Gene Therapy	treats	drug	0.90
DNA	interacts_with	gene	0.90
RNA	interacts_with	gene	0.90
Biomarker	biomarker_for	biomarker	0.90
NOTCH2NLC	associated_with	gene	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FRONTOTEMPORAL DEMENTIA in their description or question text

No additional research found