| Gene Symbol | TSC1 |
| Full Name | Tuberous Sclerosis Complex 1 |
| Aliases | TSC1PROTEIN |
| Function | It contains several functional domains including a hamartin elbow domain (HED), a transmembrane region, and a conserved tuberous sclerosis complex domain (TSC-TBD)[1]. |
| Primary Expression | neurons and plays important roles in synaptic plasticity, dendritic spine morphology, and neuronal connectivity |
| Subcellular Localization | **: The complex localizes to lysosomes through interactions with the TSC1 C-terminus |
| Molecular Weight | 130 kDa |
| Amino Acids | 164 aa |
| Pathways | mTOR Signaling, mTOR, mtor |
| Ensembl ID | ENSG00000115159 |
| GeneCards | TSC1 |
| Human Protein Atlas | TSC1 |
| Synaptic Plasticity | Local protein synthesis at synapses is controlled by mTORC1 activity |
| Neuronal Morphogenesis | mTORC1 controls dendritic arborization and axonal growth |
| Cellular Homeostasis | Autophagy regulation maintains neuronal health |
| Associated Diseases | Aging, Als, Cardiovascular, epilepsy, Ms, Tuberous sclerosis complex |
| Known Drugs/Compounds | rapamycin |
| Interactions | Akt, AKT, AKT1, AKT3, AMPK, AND |
| KG Connections | 213 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!