concept

SUMO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SUMO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

2Hypotheses

0Analyses

28Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SUMO
Key Genes/Proteins	ANXA1, RPL31, RPS3A, SRSF1PROTEIN
Linked Hypotheses	1 hypotheses

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SUMO["SUMO"]
    SUMO -->|"binds"| SRSF1PROTEIN["SRSF1PROTEIN"]
    SUMO -->|"activates"| Als["Als"]
    SUMO -->|"activates"| Cancer["Cancer"]
    SUMO -->|"activates"| Aging["Aging"]
    SUMO -->|"target for"| Neurodegeneration["Neurodegeneration"]
    SUMO -->|"target for"| Stroke["Stroke"]
    RPS3A["RPS3A"] -->|"binds"| SUMO
    RPL31["RPL31"] -->|"binds"| SUMO
    TKT["TKT"] -->|"activates"| SUMO
    IDH2["IDH2"] -->|"activates"| SUMO
    TIGAR["TIGAR"] -->|"activates"| SUMO
    PHGDH["PHGDH"] -->|"activates"| SUMO
    PRMT1["PRMT1"] -->|"activates"| SUMO
    FASN["FASN"] -->|"activates"| SUMO

Outgoing (28)

Target	Relation	Type	Str
SRSF1PROTEIN	binds	protein	0.80
Cancer	activates	disease	0.60
Aging	activates	disease	0.60
Als	associated_with	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Aging	therapeutic_target	disease	0.60
Stroke	therapeutic_target	disease	0.60
Als	regulates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Neurodegeneration	contributes_to	disease	0.60
Ischemia	protects_against	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Als	activates	disease	0.60
Mtor	activates	pathway	0.55
Apoptosis	activates	pathway	0.55
Glycolysis	activates	pathway	0.55
Mapk	therapeutic_target	pathway	0.55
Autophagy	therapeutic_target	pathway	0.55
Wnt	therapeutic_target	pathway	0.55
Mtor	therapeutic_target	pathway	0.55
Nf-Κb	activates	pathway	0.55
Autophagy	activates	pathway	0.55
Apoptosis	therapeutic_target	pathway	0.55
Oxidative Stress	therapeutic_target	pathway	0.55
Synaptic Plasticity	therapeutic_target	pathway	0.55
Epigenetic	therapeutic_target	pathway	0.55
Innate Immunity	therapeutic_target	pathway	0.55

Incoming (54)

Source	Relation	Type	Str
RPS3A	binds	gene	0.80
ANXA1	SUMOylation	protein	0.80
RPL31	binds	gene	0.70
PFKFB3	activates	gene	0.60
YTHDF1	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
METTL3	therapeutic_target	gene	0.60
IL-1	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NEURON	protects_against	gene	0.60
MICROGLIA	activates	gene	0.60
STROKE	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
GABA	therapeutic_target	gene	0.60
PHGDH	activates	gene	0.60
AMPK	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
RNA	activates	gene	0.60
CLOCK	regulates	gene	0.60
ST8SIA1	regulates	gene	0.60
JUN	regulates	gene	0.60
MFF	activates	gene	0.60
DRP1	activates	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
EGFR	activates	gene	0.60
SENP1	activates	gene	0.60
IGF2BP3	activates	gene	0.60
AKT	activates	gene	0.60
HDAC2	activates	gene	0.60
B4GALNT1	regulates	gene	0.60
PKM2	activates	gene	0.60
TKT	activates	gene	0.60
IDH2	activates	gene	0.60
TIGAR	activates	gene	0.60
PRMT1	activates	gene	0.60
FASN	activates	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
TDP-43	therapeutic_target	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
RAB11	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
RAB5	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs	0.652	neurodegeneration	What are the specific PTM changes in syn
Targeting AQP4 Sumoylation to Enhance Glymphatic Clearance a	0.490	neurodegeneration	What are the specific molecular mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SUMO in their description or question text

No additional research found

SUMO

Understanding Entity Pages

Wiki Pages (11)

Protein SUMOylation Pathway in Neurodegeneration

UBE2I — SUMO-Conjugating Enzyme

SUMOylation in Neurodegeneration

SENP2 Protein - SUMO Specific Peptidase 2

SUMO2 Protein - Small Ubiquitin-Like Modifier 2

SUMO2 — Small Ubiquitin-Like Modifier 2

SENP1 — SUMO Specific Peptidase 1

SUMO1 Protein - Small Ubiquitin-Like Modifier 1

SENP1 Protein - SUMO Specific Peptidase 1

SUMO1 — Small Ubiquitin-Like Modifier 1

SENP2 — SUMO Specific Peptidase 2