gene

SUMO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SUMO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

26Outgoing

9Incoming

0Experiments

0Debates

Summary

SUMO2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, implicated in. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SUMO2
Full Name	Small Ubiquitin-Like Modifier 2
Aliases	Page for SUMO2 Protein
Chromosome	17q25.1
Protein Family	SUMO family (ubiquitin-like)
Function	is a ubiquitin-like protein that plays critical roles in post-translational modification through SUMOylation.
Molecular Weight	10.5 kDa
Amino Acids	95 aa
Pathways	Mitophagy, Oxidative Stress, oxidative stress response
UniProt ID	[P61956](https://www.uniprot.org/uniprot/P61956)
Ensembl ID	ENSG00000193900
GeneCards	SUMO2
Human Protein Atlas	SUMO2
E1 activating enzyme	SAE1/UBA2 (SUMO-activating enzyme)
E2 conjugating enzyme	UBC9 (SUMO-conjugating enzyme)
Associated Diseases	ALS
Interactions	ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, DEMENTIA, DNA, MITOPHAGY
KG Connections	35 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SUMO2 — Small Ubiquitin-Like Modifier 2

gene · 1132 words

→

SUMO2 Protein - Small Ubiquitin-Like Modifier 2

protein · 1192 words

→

Pathway Diagram

graph TD
    SUMO2["SUMO2"]
    Ms{"Ms"}
    SUMO2 -->|"interacts with"| Ms
    Als{"Als"}
    SUMO2 -->|"interacts with"| Als
    ALS{"ALS"}
    SUMO2 -->|"interacts with"| ALS
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    SUMO2 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Dementia{"Dementia"}
    SUMO2 -->|"activates"| Dementia
    RANBP2["RANBP2"]
    SUMO2 -->|"interacts with"| RANBP2
    AND["AND"]
    SUMO2 -->|"activates"| AND
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    SUMO2 -->|"activates"| AMYOTROPHIC_LATERAL_SCLEROSIS
    DNA["DNA"]
    SUMO2 -->|"activates"| DNA
    Oxidative_Stress(["Oxidative Stress"])
    SUMO2 -->|"activates"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    SUMO2 -->|"implicated in"| neurodegeneration
    SUMO1["SUMO1"]
    SUMO1 -->|"interacts with"| SUMO2
    RANBP2 -->|"interacts with"| SUMO2
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"interacts with"| SUMO2
    AND -->|"interacts with"| SUMO2
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| SUMO2
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"activates"| SUMO2
    style SUMO2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Dementia	activates	disease	0.65
Ms	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Cardiac	activates	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
ALS	associated_with	disease	0.60
AND	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
Neuron	activates	cell_type	0.60
Mitophagy	activates	pathway	0.60
Sumo	interacts_with	protein	0.60
oxidative stress response	participates_in	pathway	0.60
RANBP2	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
SUMO1	interacts_with	gene	0.60
NDP52	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
DNA	activates	gene	0.60
PARKIN	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
PARL	activates	gene	0.60
MUL1	activates	gene	0.60
PINK1	activates	gene	0.60

Incoming (9)

Source	Relation	Type	Str
TAU	activates	gene	0.60
RNA	activates	gene	0.60
RNA	associated_with	gene	0.60
SUMO1	interacts_with	gene	0.60
RANBP2	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
DEMENTIA	activates	gene	0.60
ALZHEIMER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SUMO2 in their description or question text

No additional research found