| Gene Symbol | SENP1 |
| Full Name | SUMO Specific Peptidase 1 |
| Aliases | Page for SENP1 Protein |
| Chromosome | 2q33.1 |
| Protein Family | SENP family (SUMO proteases) |
| Protein Type | Protease |
| Function | is a cysteine protease that catalyzes deSUMOylation—the removal of SUMO (Small Ubiquitin-Like Modifier) proteins from target substrates. |
| Molecular Weight | 71 kDa |
| Amino Acids | 482 aa |
| Pathways | Apoptosis, Mitophagy, Mtor, Oxidative Stress |
| UniProt ID | [Q9Y5W4](https://www.uniprot.org/uniprot/Q9Y5W4) |
| Ensembl ID | ENSG00000142405 |
| GeneCards | SENP1 |
| Human Protein Atlas | SENP1 |
| Precursor processing | Cleaves the C-terminal diglycine motif from SUMO precursors to generate mature SUMO |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, AMPK, AND, APOPTOSIS, CANCER, CHIP |
| KG Connections | 80 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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