gene 532 words KG: SUMO1
Contents

SUMO1 — Small Ubiquitin-Like Modifier 1

🧬 Gene Info
Gene SymbolSUMO1
Full NameSmall Ubiquitin-Like Modifier 1
AliasesPage for SUMO1 Protein
Chromosome2q33
FunctionSUMO1 encodes a small ubiquitin-like protein (~101 amino acids) that can be covalently attached to lysine residues in target proteins through an enzymatic cascade involving E1, E2, and E3 enzymes.
Primary ExpressionUbiquitous - High in brain, heart, liver
Molecular Weight11.6 kDa
Amino Acids101 aa
UniProt IDP63165
NCBI Gene ID7341
Ensembl IDENSG00000116030
OMIM601561
GeneCardsSUMO1
Human Protein AtlasSUMO1
Associated DiseasesAls
InteractionsAND, ATG12, ATG5, ATG7, HIF1A, LC3
KG Connections41 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
SIRT1 (Redirect)
redirect · KG edge: inhibits
Mitofusin 1 (MFN1)
gene · KG edge: inhibits
mfn2
gene · KG edge: inhibits
NRF1 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

SUMO1 interacts_with RANBP2
RANBP2 interacts_with SUMO1
MFN1 inhibits SUMO1
SENP1 activates SUMO1
UBIQUITIN inhibits SUMO1
NRF1 inhibits SUMO1
OPA1 inhibits SUMO1
MFN2 inhibits SUMO1
TFAM inhibits SUMO1
SIRT1 inhibits SUMO1

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