gene 504 words KG: SENP2
Contents

SENP2 — SUMO Specific Peptidase 2

🧬 Gene Info
Gene SymbolSENP2
Full NameSUMO Specific Peptidase 2
AliasesPage for SENP2 Protein
Protein TypeProtease
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight68 kDa
Amino Acids589 aa
PathwaysWnt
UniProt ID[Q9Y2W1](https://www.uniprot.org/uniprot/Q9Y2W1)
GeneCardsSENP2
Human Protein AtlasSENP2
SUMO-2/3 processingPrefers SUMO-2 and SUMO-3 precursors
Chain editingEfficiently processes SUMO-2/3 chains
Spatial restrictionFunctions at the nuclear envelope
RANGAP1 processingCritically processes RANGAP1 for RanGAP1 SUMOylation
Associated Diseasesneurodegeneration
InteractionsATF3
KG Connections7 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (1)

Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (7)

Ubiquitin-Proteasome System Therapeutic Companies for P
company · KG edge: expressed_in
Neurodegeneration
disease · KG edge: implicated_in
ATF3 Gene
gene · KG edge: activates
TP53 Gene
gene · KG edge: expressed_in
UBE2I — SUMO-Conjugating Enzyme
gene · KG edge: expressed_in

Knowledge Graph (7 edges)

TP53 expressed_in SENP2
UBIQUITIN expressed_in SENP2
ATF3 activates SENP2
SENP2 expressed_in UBE2I
P53 expressed_in SENP2
SENP2 expressed_in Als
SENP2 expressed_in Ms

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