gene

RANBP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RANBP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

0Hypotheses

0Analyses

28Outgoing

4Incoming

0Experiments

0Debates

Summary

RANBP2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, implicated in. Associated with ALS, Als, Cancer. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RANBP2
Full Name	RAN Binding Protein 2
Chromosome	2q12.3
Function	RANBP2 encodes a massive 3224 amino acid protein that serves as a critical component of the nuclear pore complex (NPC).
Primary Expression	brainstem nuclei
Molecular Weight	358 kDa
Amino Acids	3224 aa
Pathways	Autophagy, Glycolysis, RANGAP1-SUMO1 Complex Formation
UniProt ID	P49792
NCBI Gene ID	9918
Ensembl ID	ENSG00000136404
OMIM	601181
GeneCards	RANBP2
Human Protein Atlas	RANBP2
Nucleocytoplasmic transport	Facilitating the bidirectional transport of proteins and RNA between nucleus and cytoplasm
Associated Diseases	Acute Necrotizing Encephalopathy
Interactions	AND, AUTOPHAGY, CKAP4, FOXO1, HIF, HIF-1Α
KG Connections	32 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RANBP2 — AlphaFold P49792 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RANBP2 — RAN Binding Protein 2

gene · 534 words

→

RANBP2 Protein

protein · 599 words

→

Pathway Diagram

graph TD
    RANBP2["RANBP2"]
    Ms{"Ms"}
    RANBP2 -->|"interacts with"| Ms
    Als{"Als"}
    RANBP2 -->|"interacts with"| Als
    Carcinoma{"Carcinoma"}
    RANBP2 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    RANBP2 -->|"activates"| Cancer
    Tumor{"Tumor"}
    RANBP2 -->|"activates"| Tumor
    ALS{"ALS"}
    RANBP2 -->|"interacts with"| ALS
    SUMO1["SUMO1"]
    RANBP2 -->|"interacts with"| SUMO1
    SUMO2["SUMO2"]
    RANBP2 -->|"interacts with"| SUMO2
    AUTOPHAGY["AUTOPHAGY"]
    RANBP2 -->|"activates"| AUTOPHAGY
    NBR1["NBR1"]
    RANBP2 -->|"activates"| NBR1
    Autophagy(["Autophagy"])
    RANBP2 -->|"activates"| Autophagy
    Glycolysis(["Glycolysis"])
    RANBP2 -->|"activates"| Glycolysis
    SUMO1 -->|"interacts with"| RANBP2
    SUMO2 -->|"interacts with"| RANBP2
    CKAP4["CKAP4"]
    CKAP4 -->|"activates"| RANBP2
    AND["AND"]
    AND -->|"interacts with"| RANBP2
    style RANBP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (28)

Target	Relation	Type	Str
UBC9	interacts_with	protein	0.95
RANGAP1	interacts_with	protein	0.95
SUMO1	exhibits_specificity_for	protein	0.90
SUMO1	exhibits_E3_ligase_activity_for	protein	0.90
RANGAP1-SUMO1 Complex Formation	regulates	process	0.85
Protease Degradation	protects_against	process	0.85
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	interacts_with	disease	0.65
Infection	activates	disease	0.65
HIF	activates	gene	0.60
SUMO1	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
SUMO2	interacts_with	gene	0.60
NBR1	activates	gene	0.60
FOXO1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
CKAP4	activates	gene	0.60
SUMO1	protects_against	entity	0.60
SUMO1	activates	entity	0.60
Sumo	interacts_with	protein	0.60
Autophagy	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
AND	activates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
HIF-1Α	activates	gene	0.60
SUMO1	interacts_with	gene	0.60
SUMO2	interacts_with	gene	0.60
CKAP4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RANBP2 in their description or question text

No additional research found