gene

RPL31

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPL31: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

7Outgoing

0Incoming

0Experiments

0Debates

Summary

RPL31 encodes a ribosomal protein component of the 60S subunit, implicated in ribosomopathies and translational dysregulation in neurodegeneration

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🧬 Gene Info

Gene Symbol	RPL31
Full Name	Ribosomal Protein L31
Chromosome	2q14.1.
Protein Type	Gene
Function	is a component of the 60S large ribosomal subunit encoded by the RPL31 gene located on chromosome 2q14.
Molecular Weight	14 kDa
Amino Acids	125 aa
Exons	5
Pathways	mtor
GeneCards	RPL31
Human Protein Atlas	RPL31
N-terminal domain	Involved in rRNA binding, particularly interactions with 28S rRNA
C-terminal region	Contributes to the peptidyl transferase center
Zinc finger motif	Some RPL31 variants contain CCHC-type zinc finger domains involved in RNA binding
Surface residues	Interact with translation factors and other ribosomal proteins
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	TREK-1
KG Connections	7 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RPL31 — Ribosomal Protein L31

gene · 1197 words

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RPL31 Protein

protein · 616 words

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Pathway Diagram

graph TD
    RPL31["RPL31"]
    TREK_1["TREK-1"]
    RPL31 -->|"interacts with"| TREK_1
    SUMO["SUMO"]
    RPL31 -->|"binds"| SUMO
    MHV_68["MHV-68"]
    RPL31 -->|"interacts with"| MHV_68
    Gene_expression["Gene expression"]
    RPL31 -->|"regulates"| Gene_expression
    Gene_expression_regulation["Gene expression regulation"]
    RPL31 -->|"participates in"| Gene_expression_regulation
    Transcription_factors["Transcription factors"]
    RPL31 -->|"regulates"| Transcription_factors
    Virulence_genes["Virulence genes"]
    RPL31 -->|"regulates"| Virulence_genes
    neurodegeneration["neurodegeneration"]
    RPL31 -->|"implicated in"| neurodegeneration
    style RPL31 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
TREK-1	interacts_with	protein	0.80
SUMO	binds	protein	0.70
Gene expression	regulates	biological_process	0.70
MHV-68	interacts_with	entity	0.70
Gene expression regulation	participates_in	biological_process	0.70
Virulence genes	regulates	gene	0.60
Transcription factors	regulates	transcription_factor	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPL31 in their description or question text

No additional research found