gene

NLGN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLGN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

37Outgoing

20Incoming

0Experiments

0Debates

Summary

NLGN3 encodes neuroligin-3, a postsynaptic cell adhesion molecule critical for synapse formation, function, and plasticity. Mutations cause autism spectrum disorder and intellectual disability, and altered NLGN3 is implicated in Alzheimer's and Parkinson's disease synaptic dysfunction.

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🧬 Gene Info

Gene Symbol	NLGN3
Full Name	Neuroligin-3
Chromosome	Xq13.1
Function	encodes a postsynaptic cell adhesion molecule that is essential for the formation, function, and plasticity of synapses throughout the mammalian brain.
Primary Expression	neurons throughout the brain, with particularly high levels in the cerebral cortex, hippocampus, and basal ganglia
Molecular Weight	165 kDa
Amino Acids	461 aa
Exons	19
Pathways	Mtor, Neuroprotection, PI3K-mTOR, PI3K-mTOR pathway
UniProt ID	Q9NZU4
NCBI Gene ID	54413
Ensembl ID	ENSG00000174373
OMIM	300336
GeneCards	NLGN3
Human Protein Atlas	NLGN3
Associated Diseases	ALS, high-grade gliomas
Interactions	ADAM10, AND, BRAIN INJURY, ERK, FAK, Fus
KG Connections	57 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NLGN3 — AlphaFold Q9NZU4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NLGN3 Gene

gene · 2091 words

→

NLGN3 Protein

protein · 656 words

→

Pathway Diagram

graph TD
    NLGN3["NLGN3"]
    synapse["synapse"]
    NLGN3 -->|"regulates"| synapse
    excitatory_synaptic_transmission["excitatory synaptic transmission"]
    NLGN3 -->|"regulates"| excitatory_synaptic_transmission
    PI3K_mTOR(["PI3K-mTOR"])
    NLGN3 -->|"activates"| PI3K_mTOR
    glioblastoma{"glioblastoma"}
    NLGN3 -->|"activates"| glioblastoma
    FAK["FAK"]
    NLGN3 -->|"activates"| FAK
    PI3K_mTOR_pathway(["PI3K-mTOR pathway"])
    NLGN3 -->|"activates"| PI3K_mTOR_pathway
    high_grade_gliomas{"high-grade gliomas"}
    NLGN3 -->|"associated with"| high_grade_gliomas
    neurodegeneration["neurodegeneration"]
    NLGN3 -->|"implicated in"| neurodegeneration
    neuronal_activity(["neuronal activity"])
    neuronal_activity -->|"regulates"| NLGN3
    ADAM10["ADAM10"]
    ADAM10 -->|"activates"| NLGN3
    ADAM10 -->|"regulates"| NLGN3
    neuronal_activity -->|"activates"| NLGN3
    ADAM10_inhibitors["ADAM10 inhibitors"]
    ADAM10_inhibitors -->|"protects against"| NLGN3
    style NLGN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (37)

Target	Relation	Type	Str
Ischemic Brain Injury	protects_against	disease	0.95
AKT	activates	entity	0.95
Oxygen-Glucose Deprivation/Reperfusion Injury	protects_against	process	0.95
MTOR	activates	protein	0.90
ERK	activates	protein	0.90
Neuronal Cell	expressed_in	cell_type	0.90
excitatory synaptic transmission	regulates	biological_process	0.80
PI3K-mTOR	activates	pathway	0.70
PI3K-mTOR pathway	activates	pathway	0.70
high-grade gliomas	associated_with	disease	0.70
glioblastoma	activates	disease	0.70
FAK	activates	protein	0.70
Als	activates	disease	0.65
ALS	activates	disease	0.65
Ischemia	activates	disease	0.65
ALS	associated_with	disease	0.60
ADAM10	inhibits	gene	0.60
NLGN1	associated_with	gene	0.60
Rb	inhibits	protein	0.60
BRAIN INJURY	activates	gene	0.60
S6K1	activates	gene	0.60
AND	activates	gene	0.60
NEURON	activates	gene	0.60
Mtor	activates	pathway	0.60
Neuron	activates	cell_type	0.60
Neuron	associated_with	cell_type	0.60
Metalloproteinase	inhibits	protein	0.60
Fus	activates	protein	0.60
neurons	expressed_in	cell_type	0.60
cortex	expressed_in	brain_region	0.60
Neuron	expressed_in	cell_type	0.55
S6K1	co_expressed_with	protein	0.50
SYNAPSE	associated_with	concept	0.50
ISCHEMIA	activates	disease	0.50
NEURONS	activates	concept	0.50
Neuroprotection	activates	process	0.50
ISCHEMIC	activates	concept	0.50

Incoming (20)

Source	Relation	Type	Str
GNAI3	mediates	protein	0.95
GNAI1	mediates	protein	0.95
neuronal activity	activates	process	0.70
ADAM10	activates	protein	0.70
neuronal activity	regulates	process	0.70
ADAM10 inhibitors	protects_against	drug	0.70
ADAM10	regulates	protein	0.70
AKT	activates	entity	0.60
MTOR	activates	entity	0.60
NEUROPROTECTION	activates	entity	0.60
SYNAPSE	associated_with	gene	0.60
AND	associated_with	gene	0.60
ERK	activates	gene	0.60
S6K1	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
NEURON	activates	gene	0.60
NLGN1	associated_with	gene	0.60
ADAM10	inhibits	gene	0.60
mTOR	activates	entity	0.50
ADAM10	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NLGN3 in their description or question text

No additional research found