protein

NRXN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRXN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

96Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

0Experiments

0Debates

Summary

NRXN1 is a protein involved in neurodegeneration research. Key relationships include: associated with, expressed in, activates. Associated with Aging, Als, Depression. Connected to 12 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NRXN1
Full Name	Neurexin-1
Chromosome	2p16.3
Function	NRXN1 encodes neurexin-1, a presynaptic cell adhesion molecule that mediates synaptic contact between neurons and is essential for synapse formation and function.
Molecular Weight	180 kDa
Pathways	Neuroprotection, Synaptic Plasticity, synaptic plasticity
UniProt ID	Q9UHB7
NCBI Gene ID	9378
Ensembl ID	ENSG00000179915
OMIM	600565
GeneCards	NRXN1
Human Protein Atlas	NRXN1
Synaptic Adhesion	Binds to neuroligins (postsynaptic) to form synaptic connections
Presynaptic Differentiation	Induces presynaptic specialization
Synaptic Transmission	Regulates neurotransmitter release
Associated Diseases	Aging, Als, Alzheimer, Schizophrenia
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APP, BSN
KG Connections	96 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NRXN1 — AlphaFold Q9UHB7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NRXN1["NRXN1"]
    Aging{"Aging"}
    NRXN1 -->|"expressed in"| Aging
    Ms{"Ms"}
    NRXN1 -->|"expressed in"| Ms
    Depression{"Depression"}
    NRXN1 -->|"expressed in"| Depression
    Als{"Als"}
    NRXN1 -->|"associated with"| Als
    Schizophrenia{"Schizophrenia"}
    NRXN1 -->|"associated with"| Schizophrenia
    BSN["BSN"]
    NRXN1 -->|"activates"| BSN
    GBA["GBA"]
    NRXN1 -->|"activates"| GBA
    CELF4["CELF4"]
    NRXN1 -->|"activates"| CELF4
    CHRNA7["CHRNA7"]
    NRXN1 -->|"associated with"| CHRNA7
    SNAP29["SNAP29"]
    NRXN1 -->|"associated with"| SNAP29
    neurodegeneration["neurodegeneration"]
    NRXN1 -->|"implicated in"| neurodegeneration
    GUT_BRAIN_AXIS["GUT-BRAIN AXIS"]
    GUT_BRAIN_AXIS -->|"regulates"| NRXN1
    style NRXN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (55)

Target	Relation	Type	Str
Aging	associated_with	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Aging	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Depression	expressed_in	disease	0.65
Als	associated_with	disease	0.65
ALS	regulates	disease	0.65
CELF4	activates	gene	0.60
synaptic plasticity	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
ALS	associated_with	disease	0.60
ALZHEIMER	regulates	gene	0.60
Presenilin	regulates	protein	0.60
SYNAPSE	activates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
Neuron	activates	cell_type	0.60
MIRNAS	expressed_in	gene	0.60
MICRORNAS	expressed_in	gene	0.60
NLGN1	interacts_with	gene	0.60
Rb	activates	protein	0.60
ALZHEIMER	activates	gene	0.60
Actin	activates	protein	0.60
BSN	activates	gene	0.60
GBA	activates	gene	0.60
CHRNA7	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RORB	activates	gene	0.60
KCNIP4	activates	gene	0.60
APP	activates	gene	0.60
NCAM2	activates	gene	0.60
RORA	activates	gene	0.60
FGF14	activates	gene	0.60
GRIN2A	activates	gene	0.60
NLGN1	activates	gene	0.60
NRXN3	regulates	gene	0.60
NRXN2	regulates	gene	0.60
NLGN1	regulates	gene	0.60
Fgf	activates	protein	0.60
Alzheimer	associated_with	disease	0.60
Prefrontal Cortex	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
NRXN3	interacts_with	gene	0.55
NRXN2	interacts_with	gene	0.55
RORA	co_discussed	gene	0.50

Incoming (41)

Source	Relation	Type	Str
LAMP2A	regulates	gene	0.60
RORA	activates	gene	0.60
KCNIP4	activates	gene	0.60
NRXN2	regulates	gene	0.60
NRXN3	regulates	gene	0.60
NLGN1	interacts_with	gene	0.60
HTT	activates	gene	0.60
LAMP2A	activates	gene	0.60
LAMP2A	inhibits	gene	0.60
GRIN2A	activates	gene	0.60
NCAM2	activates	gene	0.60
APP	activates	gene	0.60
FGF14	activates	gene	0.60
GUT-BRAIN AXIS	regulates	gene	0.60
NLGN1	activates	gene	0.60
NLGN1	regulates	gene	0.60
SYNAPSE	activates	gene	0.60
GENES	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
MIRNAS	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	expressed_in	gene	0.60
AND	interacts_with	gene	0.60
MICRORNAS	expressed_in	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
GENES	interacts_with	gene	0.50
NEURON	co_discussed	gene	0.50
NRG3	co_expressed_with	protein	0.50
NRXN3	interacts_with	gene	0.50
ALZHEIMER	activates	gene	0.50
NCAM2	co_expressed_with	gene	0.50
late	activates	disease	0.50
NRXN2	interacts_with	gene	0.50
GRIN2A	co_discussed	gene	0.50
NCAM2	co_discussed	gene	0.50
RORB	activates	gene	0.50
Neurodegeneration	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NRXN1 in their description or question text

No additional research found