gene

E2F4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about E2F4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

10Outgoing

4Incoming

0Experiments

0Debates

Summary

E2F4 is a gene implicated in neurodegeneration research. Key relationships include: treats, regulates, interacts with. Associated with Als, Cancer, Ovarian Cancer. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	E2F4
Full Name	E2F Transcription Factor 4
Chromosome	16q22.1
Protein Family	E2F transcription factor family
Protein Type	Transcription Factor
Function	encodes a member of the E2F family of transcription factors that functions primarily as a transcriptional repressor.
Primary Expression	Ubiquitous, highest in neural tissue
Pathways	autophagy
UniProt ID	Q16254
NCBI Gene ID	1882
Ensembl ID	ENSG00000173320
OMIM	601659
GeneCards	E2F4
Human Protein Atlas	E2F4
p107/p130 binding	E2F4 preferentially binds to retinoblastoma family proteins p107 and p130, forming repressive complexes
Associated Diseases	cancer_progression
Interactions	E2F2, RORA
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: E2F4 — AlphaFold Q16254 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

E2F4 Gene

gene · 2417 words

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Pathway Diagram

graph TD
    E2F4["E2F4"]
    autophagy(["autophagy"])
    E2F4 -->|"activates"| autophagy
    ATG2A["ATG2A"]
    E2F4 -->|"regulates"| ATG2A
    ULK2["ULK2"]
    E2F4 -->|"regulates"| ULK2
    cancer_progression["cancer_progression"]
    E2F4 -->|"associated with"| cancer_progression
    neurodegeneration["neurodegeneration"]
    E2F4 -->|"implicated in"| neurodegeneration
    USP2["USP2"]
    USP2 -->|"associated with"| E2F4
    style E2F4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
autophagy	activates	pathway	0.90
ATG2A	regulates	gene	0.90
ULK2	regulates	gene	0.90
cancer_progression	associated_with	phenotype	0.80
Ovarian Cancer	treats	disease	0.65
Cancer	treats	disease	0.65
Als	treats	disease	0.65
RORA	interacts_with	gene	0.60
Metastasis	treats	pathway	0.60
Chemoresistance	treats	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
USP2	associated_with	protein	0.90
TP53	treats	gene	0.60
E2F2	interacts_with	gene	0.60
CANCER	treats	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity