gene

DCAF17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DCAF17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections

0Hypotheses

0Analyses

45Outgoing

14Incoming

0Experiments

0Debates

Summary

DCAF17 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Dystonia, Ms, Neurodegeneration. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DCAF17
Full Name	DDB1 and CUL4 Associated Factor 17
Chromosome	2q31.1
Protein Type	Receptor
Function	encodes a substrate receptor component of the CUL4-DDB1 ubiquitin ligase complex.
Primary Expression	endocrine tissues and the brain, where pathogenic variants cause Woodhouse-Sakati syndrome (WSS), a rare autosomal recessive disorder characterized by
Subcellular Localization	DCAF17 localizes primarily to the:
Amino Acids	459 aa
Exons	10
Ensembl ID	ENSG00000056678
GeneCards	DCAF17
Human Protein Atlas	DCAF17
DWD box	The "DDB1-WD40" motif is required for interaction with DDB1
H-box	A conserved histidine-containing motif involved in substrate recognition
C-terminal domain	Mediates dimerization and complex assembly
Associated Diseases	ALS, Dystonia, Ms, Neurodegeneration, Parkinson
Interactions	Alpha-Synuclein, ATP13A2, CP, DAPK1, DCTN5, FA2H
KG Connections	59 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DCAF17 Gene - DDB1 and CUL4 Associated Factor 17

gene · 2411 words

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Pathway Diagram

graph TD
    DCAF17["DCAF17"]
    Neurodegeneration{"Neurodegeneration"}
    DCAF17 -->|"associated with"| Neurodegeneration
    Ms{"Ms"}
    DCAF17 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    DCAF17 -->|"associated with"| Parkinson
    Dystonia{"Dystonia"}
    DCAF17 -->|"associated with"| Dystonia
    FA2H["FA2H"]
    DCAF17 -->|"associated with"| FA2H
    C19ORF12["C19ORF12"]
    DCAF17 -->|"associated with"| C19ORF12
    PANK2["PANK2"]
    DCAF17 -->|"associated with"| PANK2
    PLA2G6["PLA2G6"]
    DCAF17 -->|"associated with"| PLA2G6
    Lipid_Metabolism(["Lipid Metabolism"])
    DCAF17 -->|"associated with"| Lipid_Metabolism
    Mitophagy(["Mitophagy"])
    DCAF17 -->|"associated with"| Mitophagy
    Autophagy(["Autophagy"])
    DCAF17 -->|"associated with"| Autophagy
    neurodegeneration["neurodegeneration"]
    DCAF17 -->|"implicated in"| neurodegeneration
    FTL["FTL"]
    FTL -->|"associated with"| DCAF17
    WDR45["WDR45"]
    WDR45 -->|"associated with"| DCAF17
    COASY["COASY"]
    COASY -->|"associated with"| DCAF17
    style DCAF17 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

Target	Relation	Type	Str
Neurodegeneration	causes	disease	0.65
Parkinson	causes	disease	0.65
ALS	causes	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Dystonia	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Als	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Mitophagy	inhibits	pathway	0.60
MITOPHAGY	inhibits	gene	0.60
Alpha-Synuclein	inhibits	protein	0.60
Ras	inhibits	protein	0.60
FA2H	associated_with	gene	0.60
C19ORF12	associated_with	gene	0.60
PANK2	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60
UBIQUITIN	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
H2AX	inhibits	gene	0.60
P62	inhibits	gene	0.60
SNCA	activates	gene	0.60
PINK1	causes	gene	0.60
UBIQUITIN	causes	gene	0.60
DCTN5	activates	gene	0.60
DAPK1	activates	gene	0.60
P62	causes	gene	0.60
FA2H	interacts_with	gene	0.60
FTL	interacts_with	gene	0.60
PANK2	interacts_with	gene	0.60
PLA2G6	interacts_with	gene	0.60
WDR45	interacts_with	gene	0.60
neurodegeneration	interacts_with	disease	0.60
Lipid Metabolism	associated_with	pathway	0.60
Mitophagy	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
PARKINSON'S DISEASE	causes	gene	0.60
ALPHA-SYNUCLEIN	causes	gene	0.60
Alpha-Synuclein	causes	pathway	0.60
Mitophagy	causes	pathway	0.60
PARKINSON	inhibits	gene	0.60
PARKINSON	causes	gene	0.60
MITOPHAGY	causes	gene	0.60
Spinal Cord	expressed_in	brain_region	0.55

Incoming (14)

Source	Relation	Type	Str
MITOPHAGY	inhibits	gene	0.60
FTL	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
COASY	associated_with	gene	0.60
P62	inhibits	gene	0.60
NEURODEGENERATION	causes	gene	0.60
DNA	causes	gene	0.60
NEUROTOXICITY	causes	gene	0.60
ATP13A2	interacts_with	gene	0.60
CP	interacts_with	gene	0.60
DAPK1	activates	gene	0.60
DCTN5	activates	gene	0.60
H2AX	causes	gene	0.60
SNCA	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DCAF17 in their description or question text

No additional research found