gene

COASY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COASY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

12Outgoing

2Incoming

0Experiments

0Debates

Summary

COASY encodes Coenzyme A synthetase, a bifunctional enzyme in CoA biosynthesis. COASY mutations cause COASY Protein-Associated Neurodegeneration (CPAN), a form of NBIA with brain iron accumulation, dystonia, and cognitive decline.

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🧬 Gene Info

Gene Symbol	COASY
Full Name	Coenzyme A Synthetase
Chromosome	17q21.2
Protein Type	Enzyme
Function	encodes a bifunctional enzyme that plays a critical role in the coenzyme A (CoA) biosynthetic pathway.
Molecular Weight	80 kDa
Amino Acids	724 aa
Exons	15
UniProt ID	Q9P2R3
NCBI Gene ID	80317
Ensembl ID	ENSG00000167468
OMIM	609856
GeneCards	COASY
Human Protein Atlas	COASY
ATP-binding motif	Required for both kinase and adenylyltransferase activities
Associated Diseases	Dystonia, Ms, Neurodegeneration, Parkinson
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: COASY — AlphaFold Q9P2R3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

COASY Gene

gene · 1155 words

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Pathway Diagram

graph TD
    COASY["COASY"]
    Neurodegeneration{"Neurodegeneration"}
    COASY -->|"associated with"| Neurodegeneration
    Ms{"Ms"}
    COASY -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    COASY -->|"associated with"| Parkinson
    Dystonia{"Dystonia"}
    COASY -->|"associated with"| Dystonia
    DCAF17["DCAF17"]
    COASY -->|"associated with"| DCAF17
    FA2H["FA2H"]
    COASY -->|"associated with"| FA2H
    C19ORF12["C19ORF12"]
    COASY -->|"associated with"| C19ORF12
    PANK2["PANK2"]
    COASY -->|"associated with"| PANK2
    PLA2G6["PLA2G6"]
    COASY -->|"associated with"| PLA2G6
    Lipid_Metabolism(["Lipid Metabolism"])
    COASY -->|"associated with"| Lipid_Metabolism
    Mitophagy(["Mitophagy"])
    COASY -->|"associated with"| Mitophagy
    Autophagy(["Autophagy"])
    COASY -->|"associated with"| Autophagy
    AKT["AKT"]
    AKT -->|"regulates"| COASY
    FTL["FTL"]
    FTL -->|"associated with"| COASY
    WDR45["WDR45"]
    WDR45 -->|"associated with"| COASY
    style COASY fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Neurodegeneration	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Dystonia	associated_with	disease	0.65
Lipid Metabolism	associated_with	pathway	0.60
Mitophagy	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
DCAF17	associated_with	gene	0.60
FA2H	associated_with	gene	0.60
C19ORF12	associated_with	gene	0.60
PANK2	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
FTL	associated_with	gene	0.60
WDR45	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COASY in their description or question text

No additional research found