gene

VPS13C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS13C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

0Hypotheses

0Analyses

25Outgoing

45Incoming

0Experiments

0Debates

Summary

Page for VPS13C Gene - Vacuolar Protein Sorting 13 Homolog C

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🧬 Gene Info

Gene Symbol	VPS13C
Full Name	Vacuolar Protein Sorting 13 Homolog C
Aliases	Page for VPS13C Gene
Chromosome	15q22.31
Function	VPS13C is a member of the VPS13 family of lipid-transfer proteins.
Molecular Weight	395 kDa
Amino Acids	100 aa
Exons	77
Pathways	cGAS-STING pathway
UniProt ID	Q9UPQ0
NCBI Gene ID	86728
Ensembl ID	ENSG00000129048
GeneCards	VPS13C
Human Protein Atlas	VPS13C
Associated Diseases	Als, Alzheimer, Ms, Parkinson, Parkinson's disease
Interactions	ATP13A2, DJ1, DNAJC6, FBXO7, GBA1, LRRK2
KG Connections	70 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VPS13C — AlphaFold Q9UPQ0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VPS13C["VPS13C"]
    Parkinson_s_disease{"Parkinson's disease"}
    VPS13C -->|"associated with"| Parkinson_s_disease
    lipid_transfer_protein["lipid transfer protein"]
    VPS13C -->|"encodes"| lipid_transfer_protein
    cGAS_STING_pathway(["cGAS-STING pathway"])
    VPS13C -->|"regulates"| cGAS_STING_pathway
    mitochondrial_DNA_accumulation(["mitochondrial DNA accumulation"])
    VPS13C -->|"activates"| mitochondrial_DNA_accumulation
    Ms{"Ms"}
    VPS13C -->|"associated with"| Ms
    MITOPHAGY["MITOPHAGY"]
    VPS13C -->|"associated with"| MITOPHAGY
    BNIP3L["BNIP3L"]
    VPS13C -->|"associated with"| BNIP3L
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    VPS13C -->|"associated with"| IMMUNE_INFILTRATION
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    VPS13C -->|"associated with"| OXIDATIVE_STRESS
    MAP1LC3B["MAP1LC3B"]
    VPS13C -->|"associated with"| MAP1LC3B
    Oxidative_Stress(["Oxidative Stress"])
    VPS13C -->|"associated with"| Oxidative_Stress
    Mitophagy(["Mitophagy"])
    VPS13C -->|"associated with"| Mitophagy
    style VPS13C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
lipid transfer protein	encodes	protein	0.70
mitochondrial DNA accumulation	activates	process	0.70
cGAS-STING pathway	regulates	pathway	0.70
Parkinson's disease	associated_with	disease	0.70
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Oxidative Stress	associated_with	pathway	0.60
PARKINSON	associated_with	gene	0.60
Mitophagy	associated_with	pathway	0.60
BNIP3L	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
stem cells	expressed_in	cell_type	0.60
VPS35	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
ATP1A3	associated_with	gene	0.60
ATP13A2	associated_with	gene	0.60

Incoming (45)

Source	Relation	Type	Str
PLA2G6	associated_with	gene	0.70
PRKN	associated_with	gene	0.70
ATP13A2	associated_with	gene	0.70
SYNJ1	interacts_with	gene	0.70
FBXO7	interacts_with	gene	0.70
PINK1	interacts_with	gene	0.70
DNAJC6	interacts_with	gene	0.70
PRKN	interacts_with	gene	0.70
ATP13A2	interacts_with	gene	0.70
SNCA	interacts_with	gene	0.60
ATP13A2	expressed_in	gene	0.60
DJ1	expressed_in	gene	0.60
DNAJC6	expressed_in	gene	0.60
FBXO7	expressed_in	gene	0.60
GBA1	expressed_in	gene	0.60
LRRK2	expressed_in	gene	0.60
PINK1	expressed_in	gene	0.60
PRKN	expressed_in	gene	0.60
SNCA	expressed_in	gene	0.60
SYNJ1	expressed_in	gene	0.60
PLA2G6	interacts_with	gene	0.60
DJ1	interacts_with	gene	0.60
GBA1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
PARK7	interacts_with	gene	0.60
GCH1	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
DNAJC13	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
LRRK2	targets	gene	0.60
RIT2	targets	gene	0.60
SCARB2	targets	gene	0.60
SNCA	targets	gene	0.60
TMEM175	targets	gene	0.60
ATP1A3	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
BAG3	targets	gene	0.60
GBA1	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VPS13C in their description or question text

No additional research found