| Gene Symbol | PLA2G6 |
| Full Name | PLA2G6 (iPLA2-VI) |
| Aliases | iPLA2-VI |
| Chromosome | 22q13.1 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | Phospholipid remodeling - generates lysophospholipids and free fatty acids |
| Mechanism of Action | Small molecule inhibitor of calcium-independent phospholipase A2 activity |
| Druggability | Low (0.36) |
| Clinical Stage | Approved |
| Molecular Weight | 90 kDa |
| Amino Acids | 752 aa |
| Pathways | Cellular senescence / SASP signaling, Ros |
| UniProt ID | Q9NP81 |
| GeneCards | PLA2G6 |
| Human Protein Atlas | PLA2G6 |
| Associated Diseases | Als, Alzheimer, Dystonia, Ms |
| Known Drugs/Compounds | BEL |
| Interactions | AND, APOPTOSIS, ATP13A2, BRAIN INJURY, C1Q, CP |
| SciDEX Target | View Target Profile (8 clinical trials) |
| KG Connections | 220 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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