gene

CP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

4Hypotheses

2Analyses

27Outgoing

4Incoming

11Experiments

2Debates

Summary

Page for CP Gene - Ceruloplasmin

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🧬 Gene Info

Gene Symbol	CP
Aliases	Page for CP Gene
Chromosome	3q24
Protein Type	Enzyme
Function	Copper transport, iron metabolism, ferroxidase activity
Primary Expression	liver, brain (astrocytes), and other tissues
Molecular Weight	151 kDa
Amino Acids	1049 aa
GeneCards	CP
Human Protein Atlas	CP
Iron metabolism	Converts Fe2+ to Fe3+ for transport
Copper transport	Carries majority of circulating copper
Antioxidant defense	Prevents iron-mediated oxidative damage
Disease associations	Aceruloplasminemia, Alzheimer's disease, Parkinson's disease, neurodegeneration
Associated Diseases	neurodegenerative_disorders, Parkinson's disease
Interactions	ATP13A2, ATP7A, ATP7B, CRH, DCAF17, FA2H
KG Connections	31 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CP Gene - Ceruloplasmin

gene · 862 words

→

A 52-Week, Open-Label Extension Study of ACP-204 in Adults With Alzheimer's D... (NCT06194799)

clinical · 3383 words

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Pathway Diagram

graph TD
    CP["CP"]
    copper["copper"]
    CP -->|"binds"| copper
    IDEDNIK_syndrome{"IDEDNIK_syndrome"}
    CP -->|"biomarker for"| IDEDNIK_syndrome
    Wilson_s_disease{"Wilson's_disease"}
    CP -->|"biomarker for"| Wilson_s_disease
    ATP7A["ATP7A"]
    CP -->|"interacts with"| ATP7A
    ATP7B["ATP7B"]
    CP -->|"interacts with"| ATP7B
    neurodegenerative_disorders{"neurodegenerative_disorders"}
    CP -->|"associated with"| neurodegenerative_disorders
    neurodegeneration["neurodegeneration"]
    CP -->|"implicated in"| neurodegeneration
    style CP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
iron-dependent ferroptosis	suppresses	process	0.90
Wilson's_disease	biomarker_for	disease	0.80
copper	binds	chemical	0.80
IDEDNIK_syndrome	biomarker_for	disease	0.80
ATP7B	interacts_with	protein	0.70
ATP7A	interacts_with	protein	0.70
HDAC2	inhibits	gene	0.60
DCAF17	interacts_with	gene	0.60
FA2H	interacts_with	gene	0.60
FTL	interacts_with	gene	0.60
PANK2	interacts_with	gene	0.60
PLA2G6	interacts_with	gene	0.60
WDR45	interacts_with	gene	0.60
neurodegeneration	interacts_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
FLT3	inhibits	gene	0.60
GABA	inhibits	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
Parkinson's disease	associated_with	disease	0.60
IR	associated_with	gene	0.60
neurodegenerative_disorders	associated_with	disease	0.60
CRH	inhibits	gene	0.60
HDAC2	activates	gene	0.60
PDGFRB	inhibits	gene	0.60
HDAC2	regulates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
CCL4	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
CCL2	associated_with	gene	0.60
ATP13A2	interacts_with	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
VCP-Mediated Autophagy Enhancement	0.787	neurodegeneration	Tau propagation mechanisms and therapeut
VCP/p97 ATPase mutations impair extraction of ubiquitinated	0.720	neurodegeneration	What are the neuron-specific effects of
Aβ-induced downregulation of circPDS5B derepresses TDP-43 mR	0.595	neurodegeneration	What mechanisms drive TDP-43 pathology s
VCP-Mediated Autophagy Enhancement	0.571	Alzheimer's Disease	Tau propagation mechanisms and therapeut

Mentioning Analyses (2)

Scientific analyses that reference this entity

Which specific factors in conditioned medium from healthy astrocytes rescue moto

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.730

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.793

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Meta-analysis of LRP1 C766T polymorphism and Alzheimer's disease susce	exploratory	Alzheimer's disease	0.950	human patients	proposed	N/A
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	cultured cells under arsenite	proposed	N/A
Endothelial CD2AP knockdown effects on memory in male mice	validation	Alzheimer's disease	0.900	male mice	proposed	N/A
Amyloid plaque load analysis in triple-mutant mouse brains	exploratory	Alzheimer's disease	0.880	APP/PSEN1/GD3S-/- triple-trans	proposed	N/A
Reelin treatment rescue via ApoER2 in CD2AP mutant mice	validation	Alzheimer's disease	0.870	mice	proposed	N/A
Network Pharmacology Analysis of Shared AD Targets	exploratory	Alzheimer's disease	0.850	Computational network analysis	proposed	N/A
MRI Phenotyping Method Concordance in Serbian AD Cohort	clinical	Alzheimer's disease	0.850	human patients	proposed	N/A
Endothelin-1 receptor A antagonist rescue in male CD2AP mice	validation	Alzheimer's disease	0.850	male mice	proposed	N/A
Endothelin-1 receptor A antagonist rescue experiment	validation	Alzheimer's disease	0.850	mice	proposed	N/A
Neuroimmune modulation and Aβ clearance mechanisms	exploratory	Alzheimer's disease	0.820	Microglia and astrocytes	proposed	N/A
Competing endogenous RNA (ceRNA) network construction	exploratory	Alzheimer's disease	0.750	computational network analysis	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury vi [PMID:41800257]	Jin X, Xue H, Shi X, Zhou Y, Zhang J, Ze	International journal of biolo	2026	0
TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1 [PMID:41799849]	Camilleri JM, Zhang J, Wang T, Ahmad I,	Autophagy reports	2026	0
Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clin [PMID:41396614]	Brown CA, Mundada NS, Cousins KAQ, Sadeg	JAMA neurology	2026	0
Membralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from th [PMID:41324484]	Zhang J, Lu X, Li S, Wang T, Ahmad I et	Adv Sci (Weinh)	2026	0
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregul [PMID:41325866]	Zhang K, Sun S, Qiu H, Zhao H, Zhao H et	J Ethnopharmacol	2026	0
Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clin [PMID:41396614]	Brown CA, Mundada NS, Cousins KAQ, Sadeg	JAMA Neurol	2026	0
Aberrant nuclear pore complex degradation contributes to neurodegeneration in VC [PMID:41475349]	Dubey SK, Chaubey D, Ikenaga C, Lin WW,	Neuron	2026	0
Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017]	Aynaashe A, Kursula P	Amino Acids	2026	0
Genetic Spectrum and Phenotypic Variability in Chinese Patients with Multisystem [PMID:41737544]	Xia X, Chen X, Sun Y, Zhang M, Qiao K et	Degener Neurol Neuromuscul Dis	2026	0
Study of Fecal Microbiota Transplantation Ameliorates Colon Morphology and Micro [PMID:41745910]	Cao X, Zhou L, Ding Y, Ma C, Chen Q et a	Vet Sci	2026	0
Effect of fermented grape pomace on growth performance and intestinal health of [PMID:41749330]	Wang M, Li Q, Guo A, Yue J, Zhang L et a	Anim Microbiome	2026	0
STUB1-VCP/p97 limits PINK1 overaccumulation to safeguard mitophagy and memory. [PMID:41964371]	Lin JY, Huang ZB, Fang EF, Lu G	Autophagy	2026	0
Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of [PMID:41988903]	Kanoria S, Veitch DP, Miller MJ, Aisen P	Alzheimers Dement	2026	0
Inhibition of PGK1 enhances sensitivity to tyrosine kinase inhibitor in T315I-mu [PMID:41909749]	Wang H, Jiang F, Pan A, Jin C, Xue Y, Li	Acta pharmaceutica Sinica. B	2026	0
Diagnostic performance of transcutaneous laryngeal ultrasound for vocal cord par [PMID:41134433]	Luo X, Xiong J, Liang S, Jiang Z, Chen H	Esophagus : official journal o	2026	0
The vital role of p97/valosin-containing protein-mediated degradation pathways i [PMID:41780115]	Phyu SM, Loh JXY, Zhao Y, Ramadan K	Current opinion in cell biolog	2026	0
Aberrant nuclear pore complex degradation contributes to neurodegeneration in VC [PMID:41475349]	Dubey SK, Chaubey D, Ikenaga C, Lin WW,	Neuron	2026	0
Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017]	Aynaashe A, Kursula P	Amino acids	2026	0
STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels. [PMID:41903135]	Lin JY, Huang ZB, Zhang SQ, Wu Y, Cheng	Cell reports	2026	0

Debates (2)

Multi-agent debates referencing this entity

Which specific factors in conditioned medium from healthy astrocytes rescue moto

active · Rounds: 4 · Score: 0.65 · 2026-04-25

The study shows VCP-mutant astrocytes exhibit hypoxia response activation withou

closed · Rounds: 4 · Score: 0.78 · 2026-04-13

Related Research

Hypotheses and analyses mentioning CP in their description or question text

No additional research found

CP

Understanding Entity Pages

Summary

Wiki Pages (21)

CP Gene - Ceruloplasmin

A 52-Week, Open-Label Extension Study of ACP-204 in Adults With Alzheimer's D... (NCT06194799)

DCPS - Decapping Enzyme

VCP→TDP-43→ALS/FTD Causal Chain

UCP4 Gene

WDPCP (WD Repeat Containing Polypeptide)

DCPS Protein (Decapping Scavenger)

UCP2 — Uncoupling Protein 2

UCP3 Gene

MECP2 — Methyl-CpG Binding Protein 2

VCP (Valosin-Containing Protein)

VCP/p97 (Valosin-Containing Protein)

CPT2

VCP — Valosin Containing Protein

VCP Protein

VCP Protein (p97)

VCP Proteostasis Modulation Therapy for ALS/FTD

ACP-204 for Alzheimer's Disease Psychosis (NCT06159673)

VCP-Targeted Therapy

VCP — Valosin-Containing Protein

CPLX1 — Complexin-1

Pathway Diagram

Outgoing (27)

Incoming (4)

Targeting Hypotheses (4)

Mentioning Analyses (2)

Which specific factors in conditioned medium from healthy astrocytes rescue moto

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

Experiments (11)

Related Papers (20)

Debates (2)

Which specific factors in conditioned medium from healthy astrocytes rescue moto

The study shows VCP-mutant astrocytes exhibit hypoxia response activation withou

Related Research