concept

CRLS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRLS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

12Outgoing

2Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CRLS1
Key Genes/Proteins	APP, CYP2E1, GPX1, KEAP1, PIKFYVE, PRDX5
Related Diseases	ALZHEIMER'S DISEASE
Related Pathways	oxidative stress response

Pathway Diagram

graph TD
    CRLS1[CRLS1]
    CRLS1 -->|interacts| GPX1[GPX1]
    CRLS1 -->|interacts| KEAP1[KEAP1]
    CRLS1 -->|interacts| PRDX5[PRDX5]
    CRLS1 -->|interacts| PRKAA1[PRKAA1]
    CRLS1 -->|interacts| SIRT1[SIRT1]
    CRLS1 -->|activates| RNF20[RNF20]
    CRLS1 -->|activates| SGMS1[SGMS1]
    CRLS1 -->|interacts| CYP2E1[CYP2E1]
    CRLS1 -->|participates in| oxidative_stress_response[oxidative stress response]
    CRLS1 -->|activates| PIKFYVE[PIKFYVE]
    APP[APP] -->|interacts| CRLS1
    benchmark_ot_ad_answer_key_CRL[benchmark_ot_ad_answer_key:CRLS1] -->|data_in| CRLS1

Outgoing (12)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CRLS1	data_in	dataset_row	0.00
ALZHEIMER'S DISEASE	associated_with	disease	0.85
RNF20	activates	gene	0.60
SGMS1	activates	gene	0.60
KEAP1	interacts_with	gene	0.60
PRDX5	interacts_with	gene	0.60
GPX1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
PIKFYVE	activates	gene	0.60
PRKAA1	interacts_with	gene	0.60
CYP2E1	interacts_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (2)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CRLS1	data_in	dataset_row	0.00
APP	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CRLS1 in their description or question text

No additional research found