gene

CRY2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRY2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

113Connections

0Hypotheses

1Analyses

50Outgoing

33Incoming

0Experiments

1Debates

Summary

Cryptochrome Circadian Regulator 2 - key circadian clock component

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🧬 Gene Info

Gene Symbol	CRY2
Full Name	Cryptochrome Circadian Regulator 2
Chromosome	4p16.3
Function	The CRY2 gene encodes Cryptochrome Circadian Regulator 2, a key component of the mammalian circadian clock.
Molecular Weight	66 kDa
Pathways	Amyloid, Cholesterol, Circadian Rhythm, Lipid Metabolism, Mtor
UniProt ID	Q96T44
NCBI Gene ID	1399
Ensembl ID	ENSG00000116771
OMIM	604961
GeneCards	CRY2
Human Protein Atlas	CRY2
Photolyase homology region (PHR)	the FAD-binding domain
Tail domain	involved in protein interactions
DAS motif	double Asp residues for FAD binding
Associated Diseases	Als, Depression, Stroke
Interactions	Actin, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APP
KG Connections	113 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CRY2 — AlphaFold Q96T44 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CRY2 Gene

gene · 716 words

→

CRY2 Protein

protein · 653 words

→

Pathway Diagram

graph TD
    CRY2["CRY2"]
    Als{"Als"}
    CRY2 -->|"associated with"| Als
    Stroke{"Stroke"}
    CRY2 -->|"associated with"| Stroke
    Depression{"Depression"}
    CRY2 -->|"associated with"| Depression
    Carcinoma{"Carcinoma"}
    CRY2 -->|"expressed in"| Carcinoma
    Cancer{"Cancer"}
    CRY2 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    CRY2 -->|"expressed in"| Tumor
    CRY2 -->|"expressed in"| Als
    Ms{"Ms"}
    CRY2 -->|"expressed in"| Ms
    Schizophrenia{"Schizophrenia"}
    CRY2 -->|"regulates"| Schizophrenia
    CLOCK["CLOCK"]
    CRY2 -->|"regulates"| CLOCK
    BMAL1["BMAL1"]
    CRY2 -->|"associated with"| BMAL1
    PER2["PER2"]
    CRY2 -->|"expressed in"| PER2
    CRY1["CRY1"]
    CRY1 -->|"associated with"| CRY2
    PER3["PER3"]
    PER3 -->|"expressed in"| CRY2
    PER1["PER1"]
    PER1 -->|"expressed in"| CRY2
    CRY1 -->|"expressed in"| CRY2
    PER3 -->|"associated with"| CRY2
    PER1 -->|"associated with"| CRY2
    NPAS2["NPAS2"]
    NPAS2 -->|"associated with"| CRY2
    PER1 -->|"regulates"| CRY2
    CRY1 -->|"regulates"| CRY2
    style CRY2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (80)

Target	Relation	Type	Str
Circadian Rhythm	expressed_in	pathway	0.70
PER2	expressed_in	gene	0.70
magnetic_field_detection	mediates	mechanism	0.70
CLOCK	expressed_in	gene	0.70
Als	activates	disease	0.65
Alzheimer	activates	disease	0.65
Als	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
circadian regulation	participates_in	pathway	0.65
Inflammation	activates	disease	0.65
Als	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Ms	activates	disease	0.65
Diabetes	activates	disease	0.65
Schizophrenia	regulates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
CLOCK GENE	expressed_in	gene	0.60
Amyloid	expressed_in	pathway	0.60
Pi3K	expressed_in	pathway	0.60
Akt	expressed_in	pathway	0.60
Neuron	activates	cell_type	0.60
Actin	activates	protein	0.60
Mtor	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
PER2	regulates	gene	0.60
BMAL1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
BMAL1	associated_with	gene	0.60
SIRT1	expressed_in	gene	0.60
PER2	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
CRY1	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
APP	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
ARNT	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
PER1	expressed_in	gene	0.60
PER1	interacts_with	gene	0.60
PER2	interacts_with	gene	0.60
CANCER	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
APP/PS1	expressed_in	gene	0.60

Incoming (33)

Source	Relation	Type	Str
PER1	expressed_in	gene	0.70
BMAL1	activates	gene	0.65
CRY1	activates	gene	0.65
CRY1	expressed_in	gene	0.60
CRY1	associated_with	gene	0.60
BMAL1	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
TRKA	activates	gene	0.60
CRY1	interacts_with	gene	0.60
CRY1	regulates	gene	0.60
NEURON	activates	gene	0.60
CLOCK	interacts_with	gene	0.60
TNF-Α	expressed_in	gene	0.60
MICROGLIA	expressed_in	gene	0.60
IL-6	expressed_in	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
APP/PS1	expressed_in	gene	0.60
PER1	regulates	gene	0.60
PER3	expressed_in	gene	0.60
PER3	associated_with	gene	0.60
PER1	associated_with	gene	0.60
NPAS2	associated_with	gene	0.60
TAU	expressed_in	gene	0.60
GFAP	activates	gene	0.60
BDNF	expressed_in	gene	0.60
MTOR	activates	gene	0.60
APP	activates	gene	0.60
PI3K	activates	gene	0.60
PER2	expressed_in	gene	0.60
AKT	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
CLOCK	expressed_in	gene	0.60
CLOCK	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What neural circuits encode and maintain multi-generational migratory route memo

spatial memory | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The paper describes memory-based migration routes maintained across generations

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning CRY2 in their description or question text

No additional research found