gene

SLC31A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC31A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

9Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for SLC31A1 — Solute Carrier Family 3 Member 1A1 (SLC31A1)

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🧬 Gene Info

Gene Symbol	SLC31A1
Full Name	Solute Carrier Family 3 Member 1A1 (SLC31A1)
Chromosome	9q32
Function	is an essential trace element required for the activity of numerous enzymes critical to energy metabolism, antioxidant defense, neurotransmitter synthesis, and iron metabolism.
Primary Expression	virtually all tissues, with particularly high expression in:
Pathways	Akt
UniProt ID	O15431
NCBI Gene ID	10551
Ensembl ID	ENSG00000137767
OMIM	603085
GeneCards	SLC31A1
Human Protein Atlas	SLC31A1
High affinity	Kd in the low micromolar to nanomolar range
Rapid kinetics	Enables efficient copper acquisition even at low extracellular concentrations
Regulated expression	CTR1 levels are adjusted based on cellular copper status
Associated Diseases	neurodegeneration
Interactions	AKT, ATF3, CLOCK, DLAT, HSP70, PER2
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC31A1 — AlphaFold O15431 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC31A1 — Solute Carrier Family 3 Member 1A1 (SLC31A1)

gene · 865 words

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Pathway Diagram

graph TD
    SLC31A1["SLC31A1"]
    Carcinoma{"Carcinoma"}
    SLC31A1 -->|"activates"| Carcinoma
    Ms{"Ms"}
    SLC31A1 -->|"activates"| Ms
    Tumor{"Tumor"}
    SLC31A1 -->|"activates"| Tumor
    PER2["PER2"]
    SLC31A1 -->|"activates"| PER2
    HSP70["HSP70"]
    SLC31A1 -->|"activates"| HSP70
    CLOCK["CLOCK"]
    SLC31A1 -->|"activates"| CLOCK
    ATF3["ATF3"]
    SLC31A1 -->|"activates"| ATF3
    DLAT["DLAT"]
    SLC31A1 -->|"activates"| DLAT
    Akt(["Akt"])
    SLC31A1 -->|"activates"| Akt
    neurodegeneration["neurodegeneration"]
    SLC31A1 -->|"implicated in"| neurodegeneration
    AKT["AKT"]
    AKT -->|"activates"| SLC31A1
    style SLC31A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
ATF3	activates	gene	0.60
DLAT	activates	gene	0.60
PER2	activates	gene	0.60
Akt	activates	pathway	0.60
HSP70	activates	gene	0.60
CLOCK	activates	gene	0.60

Incoming (1)

Source	Relation	Type	Str
AKT	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC31A1 in their description or question text

No additional research found