protein 627 words KG: PER2PROTEIN
Contents

PER2 Protein

🔬 Protein Info
Gene SymbolPeriod Circadian Regulator 2
Chromosome2p13
FunctionPER2 is a core clock gene essential for circadian rhythm generation.
Subcellular Localization</strong></td><td>Nucleus (primary), Cytoplasm</td></tr>
Molecular Weight180 kDa
PathwaysAkt, Circadian Rhythm, Lipid Metabolism, Mtor, Pi3K
UniProt IDQ8BZD0
NCBI Gene ID8864
Ensembl IDENSG00000132266
OMIM603714
bHLH DomainProtein-protein interactions
PAS-A DomainDimerization with PER1
PAS-B DomainRegulatory domain
PAS-C DomainCRY interaction
CKBDCryptochrome binding domain
Associated Diseasesneurodegeneration
KG Connections2 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Circadian Clock-Autophagy Synchronization
Score: 0.76
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (4)

Circadian gene expression effects of SD vs ketamine
exploratory · proposed · Score: 0.95
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: associated_with

Knowledge Graph (2 edges)

PER2PROTEIN participates_in circadian rhythm
PER2PROTEIN associated_with neurodegeneration

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