gene 744 words KG: PER2
Contents

PER2 Gene

🧬 Gene Info
Gene SymbolPeriod Circadian Regulator 2
Chromosome2p13
FunctionPER2 is a core clock gene essential for circadian rhythm generation.
Molecular Weight180 kDa
PathwaysAkt, Circadian Rhythm, Lipid Metabolism, Mtor, Pi3K
UniProt IDQ8BZD0
NCBI Gene ID8864
Ensembl IDENSG00000132266
OMIM603714
Associated DiseasesALS, autism spectrum disorder, Ms
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APP
KG Connections200 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (12)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Circadian Clock-Autophagy Synchronization
Score: 0.76

Related Analyses (12)

Neuroinflammation and microglial priming in early AD
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (4)

Circadian gene expression effects of SD vs ketamine
exploratory · proposed · Score: 0.95
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: expressed_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator
gene · KG edge: regulates
ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Transloc
gene · KG edge: expressed_in
ATF3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PER1 regulates PER2
CRY2 regulates PER2
CRY1 interacts_with PER2
BMAL1 interacts_with PER2
CLOCK interacts_with PER2
CLOCK regulates PER2
BMAL1 regulates PER2
PER1 expressed_in PER2
AKT expressed_in PER2
PER2 expressed_in CLOCK

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