gene 890 words KG: OMA1
Contents

OMA1 Gene

🧬 Gene Info
Gene SymbolOMA1
Full NameOMA1 Metallopeptidase
Chromosome1p36.21
Functionis a mitochondrial inner membrane metallopeptidase that plays a critical role in mitochondrial dynamics, quality control, and stress responses.
Molecular Weight57 kDa
Amino Acids524 aa
PathwaysCgas-Sting, Mitophagy, cGAS-STING Pathway, cGAS-STING pathway, mitophagy
UniProt ID[Q9Y5X4](https://www.uniprot.org/uniprot/Q9Y5X4)
Ensembl IDENSG00000174173
OMIM607356
GeneCardsOMA1
Human Protein AtlasOMA1
Associated Diseasesneurodegeneration
InteractionsAND, BECN1, BNIP3, BNIP3L, CEBPB, CGAS
KG Connections114 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
BAK1 Gene
gene · KG edge: regulates
BAX Gene
gene · KG edge: regulates
BECN1 Gene
gene · KG edge: inhibits
BNIP3 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

BNIP3 inhibits OMA1
VDAC1 inhibits OMA1
FUNDC1 inhibits OMA1
TOMM20 inhibits OMA1
TIMM9 inhibits OMA1
TIMM17B inhibits OMA1
OMA1 inhibits TIMM23
OMA1 inhibits MTOR
OMA1 inhibits NRF1
OMA1 inhibits HSPD1

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