gene 2,167 words KG: NOTCH2
Contents

NOTCH2 — Notch Receptor 2

🧬 Gene Info
Gene SymbolNOTCH2
Full NameNotch Receptor 2
Chromosome1p11
Protein TypeReceptor
Functionencodes a highly conserved transmembrane protein that serves as a critical regulator of cell fate decisions, tissue homeostasis, and developmental processes throughout the nervous and vascular syst...
Primary ExpressionCerebral cortex, Hippocampus, Vascular smooth muscle
Molecular Weight265 kDa
PathwaysPathway: An Overview, NOTCH, Notch, Notch Signaling
UniProt IDQ12983
NCBI Gene ID4853
Ensembl IDENSG00000134250
OMIM600275
GeneCardsNOTCH2
Human Protein AtlasNOTCH2
Associated DiseasesDiabetes, Glioblastoma
InteractionsABCA1, AND, AQP4, CANCER, CCL2, CDKN2A
KG Connections194 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (10)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

APC Gene
gene · KG edge: therapeutic_target
CD19 Gene
gene · KG edge: therapeutic_target
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: expressed_in
ALDH1A1 Gene
gene · KG edge: therapeutic_target
AXIN1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

DLL4 inhibits NOTCH2
LRP1 inhibits NOTCH2
NOTCH2 inhibits LRP1
NOTCH2 inhibits DLL4
BRG1 therapeutic_target NOTCH2
NRCAM therapeutic_target NOTCH2
NOTCH2 therapeutic_target EP300
NOTCH2 therapeutic_target CTNNB1
NOTCH2 therapeutic_target NEUROD1
NOTCH2 therapeutic_target MYC

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