Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about YWHAB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
YWHAB is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Infection, Parkinson, Viral Infection. Connected to 13 entities in the SciDEX knowledge graph.
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| Gene Symbol | YWHAB |
| Full Name | Tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein Beta |
| Chromosome | 20q13.13 |
| Function | YWHAB encodes 14-3-3 beta, a ubiquitously expressed isoform with critical neuronal functions |
| Molecular Weight | 28 kDa |
| Pathways | MAPK, PI3K |
| UniProt ID | YWHAB |
| NCBI Gene ID | 7533 |
| Ensembl ID | ENSG00000153013 |
| OMIM | 601290 |
| GeneCards | YWHAB |
| Human Protein Atlas | YWHAB |
| Associated Diseases | Infection, Parkinson, Viral Infection |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
YWHAB["YWHAB"]
Infection{"Infection"}
YWHAB -->|"associated_with"| Infection
Parkinson{"Parkinson"}
YWHAB -->|"associated_with"| Parkinson
Viral_Infection{"Viral Infection"}
YWHAB -->|"associated_with"| Viral_Infection
MITOPHAGY(["MITOPHAGY"])
YWHAB -->|"associated_with"| MITOPHAGY
PARKINSON_S_DISEASE(["PARKINSON'S DISEASE"])
YWHAB -->|"associated_with"| PARKINSON_S_DISEASE
ITPR2(["ITPR2"])
YWHAB -->|"associated_with"| ITPR2
style YWHAB fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | associated_with | disease | 0.65 |
| Viral Infection | associated_with | disease | 0.65 |
| Infection | associated_with | disease | 0.65 |
| VIRAL INFECTIONS | associated_with | gene | 0.60 |
| MITOPHAGY | associated_with | gene | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| Mitophagy | associated_with | pathway | 0.60 |
| ITPR2 | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| NFKB1 | associated_with | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning YWHAB in their description or question text
No additional research found