gene

NCF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

4Outgoing

7Incoming

0Experiments

0Debates

Summary

NCF2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Atherosclerosis, Ms, Stroke. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NCF2
Full Name	Neutrophil Cytosolic Factor 2
Chromosome	1q25.3
Function	NCF2 encodes the p67phox subunit of the NADPH oxidase complex.
Primary Expression	neutrophils, monocytes, and microglia
UniProt ID	P19878
NCBI Gene ID	4689
Ensembl ID	ENSG00000116701
OMIM	608512
GeneCards	NCF2
Human Protein Atlas	NCF2
Membrane components	CYBB (gp91phox) and CYBA (p22phox) - form the cytochrome b558
Associated Diseases	Atherosclerosis, Ms, Stroke
KG Connections	11 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NCF2 — AlphaFold P19878 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NCF2 Gene

gene · 560 words

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Pathway Diagram

graph TD
    NCF2["NCF2"]
    Stroke{"Stroke"}
    NCF2 -->|"associated with"| Stroke
    Ms{"Ms"}
    NCF2 -->|"associated with"| Ms
    Atherosclerosis{"Atherosclerosis"}
    NCF2 -->|"associated with"| Atherosclerosis
    Oxidative_Stress(["Oxidative Stress"])
    NCF2 -->|"associated with"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    NCF2 -->|"implicated in"| neurodegeneration
    FOS["FOS"]
    FOS -->|"associated with"| NCF2
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| NCF2
    KLF4["KLF4"]
    KLF4 -->|"associated with"| NCF2
    HSPA1A["HSPA1A"]
    HSPA1A -->|"associated with"| NCF2
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"associated with"| NCF2
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"associated with"| NCF2
    HSPA8["HSPA8"]
    HSPA8 -->|"associated with"| NCF2
    style NCF2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Stroke	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Oxidative Stress	associated_with	pathway	0.60

Incoming (7)

Source	Relation	Type	Str
FOS	associated_with	gene	0.60
KLF4	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NCF2 in their description or question text

No additional research found