| Gene Symbol | GRK3 |
| Full Name | G Protein-Coupled Receptor Kinase 3 |
| Chromosome | 22q12.1 |
| Protein Type | Kinase |
| Function | is a member of the GRK family that phosphorylates activated G protein-coupled receptors (GPCRs). |
| Primary Expression | various tissues including brain, heart, and olfactory epithelium |
| UniProt ID | [P35610](https://www.uniprot.org/uniprot/P35610) |
| Ensembl ID | ENSG00000100167 |
| OMIM | 607335 |
| GeneCards | GRK3 |
| Human Protein Atlas | GRK3 |
| Kinase domain | The catalytic domain phosphorylates serine/threonine residues on target receptors. |
| PH domain | The pleckstrin homology domain mediates membrane localization through interaction with G protein βγ subunits. |
| C-terminal targeting domain | Facilitates localization to specific membrane compartments. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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