protein

PRION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

321Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

Summary

Page for Prion Protein

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🔬 Protein Info

Gene Symbol	PRION
Chromosome	20p13
Molecular Weight	35 kDa
Amino Acids	253 aa
Pathways	Blood-Brain Barrier, Mapk, Protein Aggregation, Amyloid, Akt
GeneCards	PRION
Human Protein Atlas	PRION
Beta-sheet content and organization	Different strains exhibit distinct secondary structure compositions, with some favoring parallel beta-sheets and others antiparallel arrangements
N-terminal truncation	Different strains undergo PK cleavage at different positions, producing characteristic fragment sizes
Aggregate morphology	Electron microscopy reveals strain-specific fibril widths, branching patterns, and helical periodicity[@safar2005]
PRNP promoter polymorphisms	Affecting PrP^C expression levels
MM1/MV1 strains	Early loss of cortical and hippocampal synaptic terminals
Associated Diseases	Creutzfeldt-Jakob Disease, Cognitive Dysfunction, Motor Disorder, Behavioral Abnormalities, disease, Prion Disease
Interactions	TAU
KG Connections	29 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Prion Strain Diversity and Selective Vulnerability

experiment · 3399 words

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Pathway Diagram

graph TD
    PRION["PRION"]
    SLC6A3(["SLC6A3"])
    PRION -->|"co_discussed"| SLC6A3
    SNCA(["SNCA"])
    PRION -->|"co_discussed"| SNCA
    TUBB(["TUBB"])
    PRION -->|"co_discussed"| TUBB
    TUBB3(["TUBB3"])
    PRION -->|"co_discussed"| TUBB3
    TUBB4B(["TUBB4B"])
    PRION -->|"co_discussed"| TUBB4B
    AKT(["AKT"])
    AKT -->|"co_discussed"| PRION
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"co_discussed"| PRION
    GENES(["GENES"])
    GENES -->|"co_discussed"| PRION
    HUNTINGTON(["HUNTINGTON"])
    HUNTINGTON -->|"co_discussed"| PRION
    style PRION fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (133)

Target	Relation	Type	Str
Creutzfeldt-Jakob Disease	causes	disease	0.95
Behavioral Abnormalities	causes	phenotype	0.85
Motor Disorder	causes	phenotype	0.85
Cognitive Dysfunction	causes	phenotype	0.85
TDP-43	causes	gene	0.70
Protein Aggregation	causes	pathway	0.55
Mapk	therapeutic_target	pathway	0.55
Protein Aggregation	regulates	pathway	0.55
Blood-Brain Barrier	therapeutic_target	pathway	0.55
Oxidative Stress	contributes_to	pathway	0.55
Toll-Like Receptor	contributes_to	pathway	0.55
Akt	regulates	pathway	0.55
Pi3K	regulates	pathway	0.55
Amyloid	activates	pathway	0.55
Protein Aggregation	activates	pathway	0.55
Autophagy	associated_with	pathway	0.55
Apoptosis	causes	pathway	0.55
Amyloid	therapeutic_target	pathway	0.55
Akt	causes	pathway	0.55
Protein Aggregation	associated_with	pathway	0.55
Mitochondrial Function	regulates	pathway	0.55
Mitophagy	associated_with	pathway	0.55
SLC6A3	co_discussed	gene	0.50
SNCA	co_discussed	gene	0.50
TUBB	co_discussed	gene	0.50
TUBB3	co_discussed	gene	0.50
TUBB4B	co_discussed	gene	0.50
ALZHEIMER	interacts_with	gene	0.50
HUNTINGTON	interacts_with	gene	0.50
NEURODEGENERATIVE DISORDERS	interacts_with	concept	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
HUNTINGTON'S	interacts_with	concept	0.50
SYNUCLEIN	interacts_with	concept	0.50
ALZHEIMER	associated_with	gene	0.50
PARKINSON	associated_with	gene	0.50
Parkinson's Disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
PARKINSON	interacts_with	gene	0.50
Astrocytes	interacts_with	cell_type	0.50
Neuron	interacts_with	cell_type	0.50
NEURONS	interacts_with	concept	0.50
PARKINSON'S	interacts_with	concept	0.50
PERICYTES	interacts_with	concept	0.50
AMYLOID	causes	gene	0.50
Proteins	activates	protein	0.50
AMYLOID	activates	gene	0.50
NEURODEGENERATIVE DISORDERS	activates	concept	0.50
Chaperone	activates	pathway	0.50

Incoming (188)

Source	Relation	Type	Str
TAU	activates	protein	0.70
GLUTAMATE	activates	phenotype	0.70
INFLAMMATION	associated_with	gene	0.65
ALPHA-SYNUCLEIN	associated_with	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
ALPHA-SYNUCLEIN	causes	gene	0.65
GUT-BRAIN AXIS	causes	gene	0.65
NEURODEGENERATION	causes	gene	0.65
AND	causes	gene	0.65
PARKINSON'S DISEASE	causes	gene	0.65
PARKINSON	causes	gene	0.65
GAIN	activates	gene	0.65
NEURON	activates	gene	0.65
DEMENTIA	activates	gene	0.65
FUS	interacts_with	gene	0.65
NEURODEGENERATIVE DISORDERS	interacts_with	gene	0.65
ALS	interacts_with	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.65
DNA	interacts_with	gene	0.65
DEMENTIA	interacts_with	gene	0.65
NEURODEGENERATIVE DISEASES	causes	gene	0.65
ALZHEIMER	associated_with	gene	0.65
LRRK2	regulates	gene	0.65
LRRK2	causes	gene	0.65
ALZHEIMER DISEASE	associated_with	gene	0.65
TAU	produces	protein	0.65
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.65
ALS	activates	gene	0.65
PARKINSON	activates	gene	0.65
AMYLOID	activates	gene	0.65
ALZHEIMER	activates	gene	0.65
AND	activates	gene	0.65
NEURODEGENERATIVE DISEASES	activates	gene	0.65
ALZHEIMER'S DISEASE	activates	gene	0.65
HUNTINGTON'S DISEASE	activates	gene	0.65
PARKINSON'S DISEASE	activates	gene	0.65
HUNTINGTON	activates	gene	0.65
AQP4	activates	gene	0.65
AQUAPORIN-4	activates	gene	0.65
NEUROTOXICITY	associated_with	gene	0.65
AMYLOID	therapeutic_target	gene	0.65
NEURODEGENERATION	therapeutic_target	gene	0.65
FYN	therapeutic_target	gene	0.65
AMYLOID-BETA	therapeutic_target	gene	0.65
TAU	therapeutic_target	gene	0.65
SRC	therapeutic_target	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.65
ALS	causes	gene	0.65
DEMENTIA	causes	gene	0.65
FUS	causes	gene	0.65

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propa	6.000	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M
G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-	0.490	neurodegeneration	How do disease-associated mutations in G
Enteric Nervous System Prion-Like Propagation Blockade	0.480	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Alpha-Synuclein SAA Kinetics Study — Biological Staging Backbone for P	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiation Mechanis	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Computational Modeling of Alpha-Synuclein Propagation in PD	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,280,000
Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Alpha-Synuclein Seed Amplification Assay Validation	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation and Neuro	exploratory	Parkinson's Disease	0.400	0.50	human	proposed	$2,070,000
Antiviral Therapy Trial for Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Alpha-Synuclein Staging and Spreading in DLB — Spatial Propagation Map	validation	Parkinson's Disease	0.400	0.50	cell_line	proposed	$160,000
Genetic Risk Modifiers in DLB Phenotype	clinical	Neurodegeneration	0.400	0.50	human	proposed	$7,500,000
Tau Co-Pathology in DLB Clinical Heterogeneity	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symp [PMID:36965781]	["Ishola IO", "Awogbindin IO", "Olubodun	Neurotoxicology	2023	1
Toll-like receptor expression in the blood and brain of patients and a mouse mod [PMID:25522431]	Drouin-Ouellet J, St-Amour I, Saint-Pier	The international journal of n	2014	1
The Gut-Brain Axis Based on α-Synuclein Propagation-Clinical, Neuropatholo [PMID:40362234]	Unknown	International journal of molec	2025	0
Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeut [PMID:41465422]	Ahremenko E, Andreev A, Apushkin D, Kork	International journal of molec	2025	0
Co-exposure to polystyrene nanoplastics and glyphosate exacerbates NETs-mediated [PMID:40554107]	["Zeng H", "Qi J", "Chen Q", "Zhang R",	Ecotoxicology and environmenta	2025	0
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431]	Wang W, Wang Y, Wang F, Xie G, Liu S, Li	Phytomedicine : international	2024	0
Limonin (LM) and its derivatives: Unveiling the neuroprotective and anti-inflamm [PMID:39117089]	["Panda S", "Kesharwani A", "Singh M", "	Fitoterapia	2024	0
The role of the microbiota in glaucoma. [PMID:37866106]	Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa	Molecular aspects of medicine	2023	0
Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut micr [PMID:35652241]	["Liu S", "Kang W", "Mao X", "Ge L", "Du	Journal of pineal research	2022	0
Contriving multi-epitope vaccine ensemble for monkeypox disease using an immunoi [PMID:36311762]	["Aziz S", "Almajhdi F", "Waqas M", "Ull	Frontiers in immunology	2022	0
Galectin-3, a rising star in modulating microglia activation under conditions of [PMID:35859075]	["Garc\u00eda-Revilla J", "Boza-Serrano	Cell death & disease	2022	0
Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory [PMID:35989519]	Sawamura M, Onoe H, Tsukada H	Mov Disord	2022	0
Movement of prion-like α-synuclein along the gut-brain axis in Parkinson's disea [PMID:34043864]	Unknown	The European journal of neuros	2021	0
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocyt [PMID:31790685]	["Wu S", "Zhao M", "Sun Y", "Xie M", "Le	Life sciences	2020	0
Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061]	Choi I, Zhang Y, Seegobin SP	Nat Commun	2020	0
Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation. [PMID:32087283]	Yang L, Zhou R, Tong Y, Chen P, Shen Y,	Neurobiology of disease	2020	0
Synucleinphagy: a microglial "community cleanup program" for neuroprotection. [PMID:32453651]	["Choi I", "Seegobin S", "Liang D", "Yue	Autophagy	2020	0
Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-in [PMID:31628991]	Mezias C, Rey N, Brundin P	Neurobiol Dis	2020	0
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Mo [PMID:31255487]	["Kim S", "Kwon S", "Kam T", "Panicker N	Neuron	2019	0
Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in m [PMID:30962497]	["Zhao J", "Bi W", "Xiao S", "Lan X", "C	Scientific reports	2019	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRION in their description or question text

No additional research found