concept

AMYLOID PLAQUES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID PLAQUES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

1Analyses

27Outgoing

48Incoming

0Experiments

1Debates

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💡 Concept Info

Name	AMYLOID PLAQUES
Key Genes/Proteins	ADAM10, AMYLOID, APOE, APOE4, APP
Related Diseases	ALZHEIMER'S DISEASE, CEREBRAL AMYLOID ANGIOPATHY

Pathway Diagram

graph TD
    AMYLOID_PLAQUES["AMYLOID PLAQUES"]
    AMYLOID_PLAQUES -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    AMYLOID_PLAQUES -.biomarker for.-> Alzheimer_S_Disease["Alzheimer'S Disease"]
    AMYLOID_PLAQUES -->|"correlates_with"| Lipid_Droplet_Load["Lipid Droplet Load"]
    AMYLOID_PLAQUES -->|"causes"| Neurodegeneration["Neurodegeneration"]
    AMYLOID_PLAQUES -.biomarker for.-> Alzheimer_Disease["Alzheimer Disease"]
    AMYLOID_PLAQUES -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    AMYLOID_PLAQUES -->|"interacts"| NEURODEGENERATION["NEURODEGENERATION"]
    APP["APP"] -->|"causes"| AMYLOID_PLAQUES
    Amyloid_Beta["Amyloid Beta"] -->|"mediates"| AMYLOID_PLAQUES
    microglial_efferocytosis["microglial efferocytosis"] -->|"activates"| AMYLOID_PLAQUES
    alpha_synuclein["alpha-synuclein"] -->|"activates"| AMYLOID_PLAQUES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"interacts"| AMYLOID_PLAQUES
    ASTROCYTES["ASTROCYTES"] -->|"interacts"| AMYLOID_PLAQUES
    MICROGLIA["MICROGLIA"] -->|"activates"| AMYLOID_PLAQUES
    Microglia_Replacement["Microglia Replacement"] -->|"suppresses"| AMYLOID_PLAQUES

Outgoing (27)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.98
Alzheimer'S Disease	biomarker_for	disease	0.95
Lipid Droplet Load	correlates_with	phenotype	0.90
Alzheimer's Disease	biomarker_for	disease	0.90
Neurodegeneration	causes	process	0.85
Alzheimer Disease	biomarker_for	disease	0.85
Complement Activation	associated_with	process	0.80
Mild Cognitive Impairment	biomarker_for	disease	0.80
Alzheimer's disease	biomarker_for	disease	0.70
INFLAMMATION	causes	phenotype	0.65
TAU	protects_against	protein	0.65
TAU	phosphorylates	protein	0.65
NEURODEGENERATION	interacts_with	phenotype	0.65
CEREBRAL AMYLOID ANGIOPATHY	produces	disease	0.65
CEREBRAL AMYLOID ANGIOPATHY	causes	disease	0.65
ALZHEIMER'S DISEASE	produces	disease	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
METFORMIN	protects_against	drug	0.65
INFLAMMATION	produces	phenotype	0.65
ALZHEIMER'S DISEASE	expressed_in	disease	0.55
CA1	associated_with	brain_region	0.50
ADUCANUMAB	associated_with	drug	0.45
METFORMIN	associated_with	drug	0.45
DONANEMAB	associated_with	drug	0.45
CORTEX	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
LECANEMAB	associated_with	drug	0.45

Incoming (48)

Source	Relation	Type	Str
ABCA7 Deletion	upregulates	phenotype	0.95
APP	causes	gene	0.92
Amyloid Beta	mediates	protein	0.90
Al002C	associated_with	drug	0.90
38493185	was increased in microglia near	paper	0.90
Amyloid-β	associated_with	protein	0.90
29552443	were almost undetectable in	paper	0.90
APP	associated_with	gene	0.90
29552443	exhibit almost undetectable	paper	0.90
TREM2	associated_with	protein	0.88
SGMS1	associated_with	protein	0.88
Aged Microglia	associated_with	cell_type	0.80
microglia	associated_with	cell_type	0.70
NEURONS	regulates	cell_type	0.70
alpha-synuclein	activates	protein	0.70
cystatin C	reduces	protein	0.70
microglial efferocytosis	activates	process	0.70
NEURODEGENERATION	inhibits	phenotype	0.70
PHAGOCYTOSIS	transports	phenotype	0.65
ADAM10	interacts_with	gene	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
ASTROCYTES	interacts_with	cell_type	0.65
MICROGLIA	activates	cell_type	0.65
ALZHEIMER'S DISEASE	inhibits	disease	0.65
MICROGLIA	causes	cell_type	0.65
MICROGLIA	regulates	cell_type	0.65
LECANEMAB	causes	drug	0.65
DONANEMAB	protects_against	drug	0.65
AMYLOID	causes	protein	0.65
APOE	inhibits	gene	0.65
APOE	regulates	gene	0.65
MICROGLIA	protects_against	cell_type	0.65
AMYLOID	inhibits	protein	0.65
AMYLOID	increases_risk	protein	0.65
MICROGLIA	interacts_with	cell_type	0.65
ADAM10	produces	gene	0.65
APP	degrades	gene	0.65
ALZHEIMER'S DISEASE	implicated_in	disease	0.60
ADAM10	expressed_in	gene	0.55
AMYLOID	participates_in	protein	0.55
INFLAMMATION	expressed_in	phenotype	0.55
TAU	associated_with	protein	0.50
ENTORHINAL CORTEX	associated_with	brain_region	0.45
APOE4	associated_with	gene	0.45
APOE	associated_with	gene	0.45
CEREBRAL CORTEX	associated_with	brain_region	0.45
BDNF	interacts_with	gene	0.40
Microglia Replacement	suppresses	process	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other

neurodegeneration | 2026-04-25 | 8 hypotheses Top: 0.640

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

Related Research

Hypotheses and analyses mentioning AMYLOID PLAQUES in their description or question text

No additional research found