concept

ENDOSOMES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOSOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

537Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ENDOSOMES is a concept in neurodegeneration research. Key relationships include: activates, interacts with, expressed in. Associated with ALS, Aging, Als. Connected to 253 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ENDOSOMES
Key Genes/Proteins	Actin, AGING, AKT, ALS2, ALZHEIMER, ALZHEIMER DISEASE
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt, Amyloid

Pathway Diagram

graph TD
    ENDOSOMES["ENDOSOMES"]
    ENDOSOMES -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    ENDOSOMES -->|"expressed in"| Als["Als"]
    ENDOSOMES -->|"expressed in"| Ms["Ms"]
    ENDOSOMES -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ENDOSOMES -->|"expressed in"| Dementia["Dementia"]
    ENDOSOMES -->|"activates"| Tumor["Tumor"]
    ENDOSOMES -->|"regulates"| Aging["Aging"]
    C9ORF72["C9ORF72"] -->|"binds"| ENDOSOMES
    ATM["ATM"] -->|"expressed in"| ENDOSOMES
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| ENDOSOMES
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"interacts"| ENDOSOMES
    VESICLE_TRAFFICKING["VESICLE TRAFFICKING"] -->|"interacts"| ENDOSOMES
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"interacts"| ENDOSOMES
    C9ORF72_REPEAT_EXPANSION["C9ORF72 REPEAT EXPANSION"] -->|"expressed in"| ENDOSOMES
    CHMP2B["CHMP2B"] -->|"expressed in"| ENDOSOMES
    OPTN["OPTN"] -->|"expressed in"| ENDOSOMES

Outgoing (312)

Target	Relation	Type	Str
Als	interacts_with	disease	0.75
ALS	causes	disease	0.75
Ataxia	associated_with	disease	0.75
EGF	activates	gene	0.70
Neuroinflammation	activates	disease	0.65
ALS	interacts_with	disease	0.65
Ms	expressed_in	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	causes	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Dementia	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Ms	regulates	disease	0.65
Als	inhibits	disease	0.65
Glioblastoma	inhibits	disease	0.65
Parkinson	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Ms	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Stroke	transports	disease	0.65
Ms	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Tumor	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Dementia	regulates	disease	0.65
Ftd	regulates	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Ftd	causes	disease	0.65
Ms	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Inflammation	inhibits	disease	0.65

Incoming (225)

Source	Relation	Type	Str
C9ORF72	interacts_with	protein	0.90
C9ORF72	binds	gene	0.90
C9ORF72	interacts_with	gene	0.74
ATM	expressed_in	protein	0.70
LC3	activates	gene	0.60
EXOSOMES	transports	gene	0.60
RAB5	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60
FIG4	expressed_in	gene	0.60
ALS2	expressed_in	gene	0.60
ALS	causes	gene	0.60
SQSTM1	causes	gene	0.60
DEMENTIA	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
TSC2	activates	gene	0.60
TFEB	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
GENES	activates	gene	0.60
ATG	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ENDOSOME	associated_with	gene	0.60
ATG5	implicated_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
OPTN	causes	gene	0.60
EEA1	activates	gene	0.60
ENDOSOME	interacts_with	gene	0.60
SORL1	regulates	gene	0.60
SORCS1	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
SORL1	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
APP/PS1	inhibits	gene	0.60
AKT	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
RAB11	expressed_in	gene	0.60
CACNA1G	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
TRKB	expressed_in	gene	0.60
RAB7	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
BDNF	interacts_with	gene	0.60
TRKB	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
RAB27B	inhibits	gene	0.60
RNA	inhibits	gene	0.60
RAB27A	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 7 hypotheses Top: 0.533

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning ENDOSOMES in their description or question text

No additional research found