gene

LRP10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

26Outgoing

5Incoming

0Experiments

0Debates

Summary

LRP10 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, associated with, inhibits. Associated with Alzheimer, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LRP10
Protein Type	Receptor
Function	LRP10 is a transmembrane receptor protein involved in
Primary Expression	neurons and has been implicated in endosomal-lysosomal trafficking and protein clearance pathways
GeneCards	LRP10
Human Protein Atlas	LRP10
Associated Diseases	Parkinson's disease
Interactions	ALZHEIMER'S DISEASE, APP, ENDOSOMES, SORL1
KG Connections	31 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LRP10

gene · 624 words

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LRP10 Protein

protein · 644 words

→

Pathway Diagram

graph TD
    LRP10["LRP10"]
    TREM2["TREM2"]
    LRP10 -->|"associated with"| TREM2
    LRP10 -->|"expressed in"| TREM2
    Alzheimer{"Alzheimer"}
    LRP10 -->|"expressed in"| Alzheimer
    Ms{"Ms"}
    LRP10 -->|"expressed in"| Ms
    LRP10 -->|"inhibits"| Alzheimer
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    LRP10 -->|"inhibits"| ALZHEIMER_S_DISEASE
    LDLR["LDLR"]
    LRP10 -->|"associated with"| LDLR
    APP["APP"]
    LRP10 -->|"activates"| APP
    ENDOSOMES["ENDOSOMES"]
    LRP10 -->|"activates"| ENDOSOMES
    neurodegeneration["neurodegeneration"]
    LRP10 -->|"implicated in"| neurodegeneration
    ALZHEIMER_S_DISEASE -->|"expressed in"| LRP10
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"expressed in"| LRP10
    APOE["APOE"]
    APOE -->|"associated with"| LRP10
    style LRP10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

Target	Relation	Type	Str
TREM2	associated_with	gene	0.80
TREM2	expressed_in	gene	0.70
Alzheimer	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
ENDOSOMES	activates	gene	0.60
App	expressed_in	protein	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
APOE	expressed_in	gene	0.60
Rb	expressed_in	protein	0.60
LDLR	associated_with	gene	0.60
APP	activates	gene	0.60
neurodegeneration	activates	disease	0.60
SORL1	interacts_with	gene	0.60
SORL1	regulates	gene	0.60
neurodegeneration	translocates_to	disease	0.60
ALZHEIMER	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
Parkinson's disease	interacts_with	disease	0.60
ALS	expressed_in	disease	0.60
oxidative stress response	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
stem cells	expressed_in	cell_type	0.60
Parkinson's disease	associated_with	disease	0.60

Incoming (5)

Source	Relation	Type	Str
ALZHEIMER	expressed_in	gene	0.60
APOE	associated_with	gene	0.60
APOE	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
MICROGLIA	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LRP10 in their description or question text

No additional research found