protein

PGC-1Α

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGC-1Α: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

108Connections

3Hypotheses

6Analyses

50Outgoing

36Incoming

2Experiments

13Debates

Summary

Page for PGC-1α Protein

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🔬 Protein Info

Gene Symbol	PGC
Full Name	1α Protein
Function	Pgc 1Α Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	PGC
Human Protein Atlas	PGC
PPARGC1A gene	Encoding locus for PGC-1α
NRF1/NRF2	Nuclear respiratory
Associated Diseases	Neurodegenerative Diseases
Interactions	ALZHEIMER, AMPK, HSP90, LAMP2, LAMP2A, MEF2C
KG Connections	81 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PGC-1α Protein

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Pathway Diagram

graph TD
    PGC_1_["PGC-1Alpha"]
    TUG_CLEAVAGE_PRODUCT["TUG CLEAVAGE PRODUCT"]
    TUG_CLEAVAGE_PRODUCT -->|"interacts with"| PGC_1_
    PPAR["PPAR"]
    PGC_1_ -->|"activates"| PPAR
    GLUT4["GLUT4"]
    PGC_1_ -->|"activates"| GLUT4
    GENE_EXPRESSION["GENE EXPRESSION"]
    PGC_1_ -->|"activates"| GENE_EXPRESSION
    NUCLEUS["NUCLEUS"]
    PGC_1_ -->|"activates"| NUCLEUS
    PEROXISOME["PEROXISOME"]
    PGC_1_ -->|"activates"| PEROXISOME
    NEURONS["NEURONS"]
    PGC_1_ -->|"activates"| NEURONS
    INTERNEURONS["INTERNEURONS"]
    PGC_1_ -->|"activates"| INTERNEURONS
    NEURONS["NEURONS"]
    PGC_1_ -->|"protects against"| NEURONS
    INTERNEURONS["INTERNEURONS"]
    PGC_1_ -->|"protects against"| INTERNEURONS
    NEURONS["NEURONS"]
    PGC_1_ -->|"interacts with"| NEURONS
    Differentiation["Differentiation"]
    PGC_1_ -->|"interacts with"| Differentiation
    GENE_EXPRESSION["GENE EXPRESSION"]
    PGC_1_ -->|"interacts with"| GENE_EXPRESSION
    INTERNEURONS["INTERNEURONS"]
    PGC_1_ -->|"interacts with"| INTERNEURONS
    PPAR__["PPAR-Gamma"]
    PGC_1_ -->|"activates"| PPAR__
    Neuroprotection["Neuroprotection"]
    PGC_1_ -->|"activates"| Neuroprotection
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    PGC_1_ -->|"activates"| MITOCHONDRIAL_DNA
    Proteins["Proteins"]
    PGC_1_ -->|"activates"| Proteins
    cancer["cancer"]
    PGC_1_ -->|"activates"| cancer
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    PGC_1_ -->|"activates"| OXIDATIVE_PHOSPHORYLATION
    METASTASIS["METASTASIS"]
    PGC_1_ -->|"activates"| METASTASIS
    cancer["cancer"]
    PGC_1_ -->|"expressed in"| cancer
    cancer["cancer"]
    PGC_1_ -->|"inhibits"| cancer
    METASTASIS["METASTASIS"]
    PGC_1_ -->|"inhibits"| METASTASIS
    Invasion["Invasion"]
    PGC_1_ -->|"activates"| Invasion
    ALZHEIMER["ALZHEIMER"]
    PGC_1_ -->|"activates"| ALZHEIMER
    mitophagy["mitophagy"]
    PGC_1_ -->|"activates"| mitophagy
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    PGC_1_ -->|"activates"| Alzheimer_S_Disease
    AMPK["AMPK"]
    PGC_1_ -->|"activates"| AMPK
    disease["disease"]
    PGC_1_ -->|"activates"| disease

Outgoing (72)

Target	Relation	Type	Str
mitochondrial biogenesis	promotes	process	0.95
Mitochondrial Biogenesis	promotes	process	0.90
mitochondrial biogenesis	regulates	process	0.90
oxidative_metabolism	activates	pathway	0.90
mitochondrial biogenesis	activates	process	0.90
Pv+ Interneurons	regulates	cell_type	0.90
Mitochondrial Function	regulates	process	0.85
Structural, Electrophysiological, Synaptic, And Metabolic Features	regulates	phenotype	0.80
SIRT3	activates	protein	0.70
mitophagy	activates	process	0.70
NLRP3	inhibits	protein	0.70
neuroinflammation	inhibits	process	0.70
Nrf2	interacts_with	protein	0.70
MFN2	regulates	protein	0.70
Schwann cells	expressed_in	cell_type	0.70
mitochondrial biogenesis	regulates	process	0.70
ULK1	activates	protein	0.70
Alzheimer's disease	protects_against	disease	0.60
OXIDATIVE PHOSPHORYLATION	activates	pathway	0.50
cancer	expressed_in	disease	0.50
cancer	inhibits	disease	0.50
Invasion	activates	pathway	0.50
EXERCISE	activates	concept	0.50
RAPAMYCIN	inhibits	concept	0.50
UBIQUITIN	regulates	protein	0.50
Ubiquitin-Proteasome	regulates	pathway	0.50
Chaperone	regulates	pathway	0.50
FBXW7	regulates	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	regulates	concept	0.50
PARKINSON	activates	gene	0.50
Parkinson's Disease	activates	disease	0.50
PARKINSON'S	activates	concept	0.50
UBIQUITIN	activates	protein	0.50
Ubiquitin-Proteasome	activates	pathway	0.50
FBXW7	activates	concept	0.50
NEURONS	regulates	concept	0.50
Chaperone	activates	pathway	0.50
CHAPERONE-MEDIATED AUTOPHAGY	activates	concept	0.50
DOPAMINERGIC	activates	concept	0.50
Neurodegenerative Diseases	associated_with	disease	0.50
Neurodegenerative Diseases	activates	disease	0.50
PROTEIN MISFOLDING	associated_with	concept	0.50
UBIQUITIN	associated_with	protein	0.50
Proteins	associated_with	protein	0.50
cancer	activates	disease	0.50
NUCLEUS	activates	concept	0.50
PEROXISOME	activates	concept	0.50
NEURONS	activates	concept	0.50
INTERNEURONS	activates	concept	0.50
PPAR	activates	protein	0.50

Incoming (36)

Source	Relation	Type	Str
SIRT1	activates	protein	0.90
TUG CLEAVAGE PRODUCT	interacts_with	entity	0.90
AMPK	activates	protein	0.85
Neural Activity	activates	process	0.80
PM10	downregulates	compound	0.80
PPARGC1A	encodes	gene	0.70
SIRT3	regulates	enzyme	0.70
SIRT1	regulates	enzyme	0.70
PPAR-γ	interacts_with	protein	0.70
SIRT1 activation	activates	protein	0.70
AMPK	regulates	protein	0.70
Copper	inhibits	drug	0.70
FBXW7	inhibits	protein	0.60
MEF2C	co_discussed	gene	0.50
NEURON	co_discussed	gene	0.50
PGC-1	co_discussed	protein	0.50
Neurodegeneration	associated_with	disease	0.50
TFAM	inhibits	gene	0.50
mTOR	inhibits	entity	0.50
NRF1	inhibits	gene	0.50
MEF2C	inhibits	gene	0.50
Autophagy	activates	process	0.50
MITOCHONDRIA	regulates	cell_type	0.50
LAMP2	activates	protein	0.50
LAMP2A	activates	gene	0.50
HSP90	activates	protein	0.50
MITOCHONDRIA	inhibits	cell_type	0.50
Autophagy	regulates	process	0.50
MEF2C	interacts_with	gene	0.50
SIRT3	activates	gene	0.50
TFAM	activates	gene	0.50
NRF1	activates	gene	0.50
MITOCHONDRIA	activates	cell_type	0.50
PPARGC1A	activates	gene	0.50
SIRT1	deacetylation	gene	0.50
NRF2	activates	gene	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resil	0.778	neurodegeneration	Gut Microbiome Analysis in Parkinson's D
APOE4 drives astrocyte metabolic reprogramming toward glycol	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat
HBOT at 2.0 ATA for 60 minutes restores PGC-1α-mediated mito	0.520	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (6)

Scientific analyses that reference this entity

Comparative epigenetic signatures across AD, PD, and ALS

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.550

test debate

neurodegeneration | 2026-04-15 | 0 hypotheses

What neural circuits encode and maintain multi-generational migratory route memo

spatial memory | 2026-04-08 | 7 hypotheses Top: 0.455

What is the optimal therapeutic window for microglial reprogramming before irrev

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.735

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PGC-1α knockout analysis of PV+ interneuron maturation	validation	neurodevelopmental disorders	0.850	0.00	knockout mice	proposed	N/A
PV+ interneuron subtype diversification analysis	exploratory	neurodevelopmental disorders	0.750	0.00	mouse cortical PV+ interneuron	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018