| Gene Symbol | CAMK2A |
| Full Name | Calcium/Calmodulin-Dependent Protein Kinase II Alpha |
| Protein Type | Serine/Threonine Kinase |
| Function | Calcium/Calmodulin-Dependent Protein Kinase II alpha (CaMKIIα) is a serine/threonine kinase that serves as a central mediator of synaptic plasticity, learning, and memory |
| Molecular Weight | 54.1 kDa (monomer) |
| Pathways | Hepatic Mitochondrial Oxidation, Intrahepatic Lipolysis, Neuronal Regeneration, Neuroregeneration, epigenetic regulation |
| UniProt ID | [Q9UQM7](https://www.uniprot.org/uniprot/Q9UQM7) |
| GeneCards | CAMK2A |
| Human Protein Atlas | CAMK2A |
| Kinase domain | Catalytic domain with ATP and substrate binding sites |
| Regulatory segment | Contains autoinhibitory region and calmodulin-binding domain |
| Variable linker | Provides flexibility for hub assembly |
| Association domain (hub) | Mediates dodecameric assembly |
| 12-14 subunits | Assemble into wheel-like structure |
| Subunit exchange | Active subunits can transactivate other holoenzymes |
| Associated Diseases | Als, epilepsy, Ms, neuroscience |
| Known Drugs/Compounds | Cytosolic Calcium |
| Interactions | ARC, ATM, BDNF, BRCA1, BRD4, DLG4 |
| SciDEX Hypotheses | CaMKII-Dependent Synaptic Circuit Amplification |
| KG Connections | 148 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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