concept

MTHFR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTHFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

12Outgoing

32Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MTHFR
Key Genes/Proteins	ABCB1, ABCG2, ACE, ADRA2A, ADRB2, APLP1
Related Diseases	Alzheimer's disease
Related Pathways	autophagy pathway

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MTHFR (Methylenetetrahydrofolate Reductase)

entity · 2515 words

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Pathway Diagram

graph TD
    MTHFR[MTHFR]
    MTHFR -->|interacts| SOD1[SOD1]
    MTHFR -->|participates in| autophagy_pathway[autophagy pathway]
    MTHFR -->|data_in| benchmark_ot_ad_answer_key_MTH[benchmark_ot_ad_answer_key:MTHFR]
    APLP1[APLP1] -->|interacts| MTHFR
    APOE[APOE] -->|interacts| MTHFR
    CLDN5[CLDN5] -->|interacts| MTHFR
    MMP9[MMP9] -->|interacts| MTHFR
    resveratrol[resveratrol] -->|targets| MTHFR
    curcumin[curcumin] -->|targets| MTHFR
    DRD2[DRD2] -->|interacts| MTHFR
    HOMER1[HOMER1] -->|interacts| MTHFR
    levodopa[levodopa] -->|targets| MTHFR
    ACE[ACE] -->|activates| MTHFR

Outgoing (12)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:MTHFR	data_in	dataset_row	0.00
Hyper-Homocysteinemia	associated_with	phenotype	0.85
levodopa adverse drug reactions	associated_with	phenotype	0.75
NBEA	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
SOD1	interacts_with	gene	0.60
Alzheimer's disease	associated_with	disease	0.60
autophagy pathway	participates_in	pathway	0.60

Incoming (32)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:MTHFR	data_in	dataset_row	0.00
levodopa	targets	drug	0.60
ACE	activates	gene	0.60
ACE	associated_with	gene	0.60
LDL	activates	gene	0.60
CYP1A2	associated_with	gene	0.60
CYP2E1	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
APLP1	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
CLDN5	interacts_with	gene	0.60
MMP9	interacts_with	gene	0.60
resveratrol	targets	drug	0.60
curcumin	targets	drug	0.60
ABCB1	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
APOE	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
COMT	associated_with	gene	0.60
CYP2C19	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
DRD2	interacts_with	gene	0.60
HOMER1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MTHFR in their description or question text

No additional research found